Current patient management of chronic myeloid leukemia in Latin America

Jorge Cortes, Carmino De Souza, Manuel Ayala-Sanchez, Israel Bendit, Carlos Best-Aguilera, Alicia Enrico, Nelson Hamerschlak, Katia Pagnano, Ricardo Pasquini, Luis Meillon

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background: Treatment recommendations have been developed for management of patients with chronic myeloid leukemia (CML). Methods: A 30-item multiple-choice questionnaire was administered to 435 hematologists and oncohematologists in 16 Latin American countries. Physicians self-reported their diagnostic, therapeutic, and disease management strategies. Results: Imatinib is available as initial therapy to 92% of physicians, and 42% of physicians have access to both second-generation tyrosine kinase inhibitors. Standard-dose imatinib is the preferred initial therapy for most patients, but 20% would manage a young patient initially with an allogeneic stem cell transplant from a sibling donor, and 10% would only offer hydroxyurea to an elderly patient. Seventy-two percent of responders perform routine cytogenetic analysis for monitoring patients on therapy, and 59% routinely use quantitative polymerase chain reaction. For patients who fail imatinib therapy, 61% would increase the dose of imatinib before considering change to a second-generation tyrosine kinase inhibitor, except for patients aged 60 years, for whom a switch to a second-generation tyrosine kinase inhibitor was the preferred choice. Conclusions: The answers to this survey provide insight into the management of patients with CML in Latin America. Some deviations from current recommendations were identified. Understanding the treatment patterns of patients with CML in broad population studies is important to identify needs and improve patient care.

Original languageEnglish (US)
Pages (from-to)4991-5000
Number of pages10
JournalCancer
Volume116
Issue number21
DOIs
StatePublished - Nov 1 2010

    Fingerprint

Keywords

  • Chronic myeloid leukemia
  • Dasatinib
  • Guidelines
  • Imatinib
  • Latin America
  • Nilotinib
  • Survey
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cortes, J., De Souza, C., Ayala-Sanchez, M., Bendit, I., Best-Aguilera, C., Enrico, A., Hamerschlak, N., Pagnano, K., Pasquini, R., & Meillon, L. (2010). Current patient management of chronic myeloid leukemia in Latin America. Cancer, 116(21), 4991-5000. https://doi.org/10.1002/cncr.25273