Cutaneous squamous cell carcinoma of the lip

A population-based analysis

Aykut A Unsal, Aylin B. Unsal, Tara E. Henn, Soly Baredes, Jean Anderson Eloy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives/Hypothesis: The role of cumulative ultraviolet (UV) radiation in cutaneous squamous cell carcinoma of the lip (CSCCL) is well understood. This study seeks to evaluate overall survival as well as incidence and demographics across geographic regions, given differences in UV exposure across the United States. Study Design: Retrospective population-based analysis. Methods: A total of 14,901 CSCCL cases were identified as being from the West, Midwest, South, or Northeast, utilizing the Surveillance, Epidemiology, and End Results registry from 1973 to 2013. Demographics, stage of disease, and treatment modalities were compared among regions. Results: Of the CSCCL cases reported, 58.3%, 24.5%, 10.8%, and 6.4% originated from the West, Midwest, South, and Northeast, respectively. Patients most commonly presented with T1 tumors (81.3%), and nodal and distant metastasis was rare for patients from all regions (3.1% and 0.3%, respectively). Patients with American Joint Committee on Cancer stage II and higher were most likely from the Northeast or South. Overall, most patients were treated with surgery monotherapy (89.5%); however, surgical monotherapy was least commonly utilized in patients in the Northeast and South. Overall 5-year disease specific survival was measured at 94.7%. Conclusion: Although areas of high UV index are implicated in increased morbidity and mortality due to CSCCL, this study indicates that a variety of factors play a role in CSCCL incidence and outcomes in the United States. The elderly and non-white populations were identified as poor prognostic demographic factors. Investigation detailing differences in CSCCL detection and treatment may aid in the identification of higher-risk populations. Level of Evidence: 4. Laryngoscope, 128:84–90, 2018.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalLaryngoscope
Volume128
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Lip
Squamous Cell Carcinoma
Skin
Population
Demography
Laryngoscopes
Survival
Incidence
Registries
Neoplasms
Epidemiology
Retrospective Studies
Radiation
Neoplasm Metastasis
Morbidity
Mortality
Therapeutics

Keywords

  • Cutaneous squamous cell carcinoma of the lip
  • SEER
  • cutaneous head and neck cancer
  • head and neck cancer
  • lip cancer
  • population-based
  • surveillance epidemiology and end results
  • survival

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Unsal, A. A., Unsal, A. B., Henn, T. E., Baredes, S., & Eloy, J. A. (2018). Cutaneous squamous cell carcinoma of the lip: A population-based analysis. Laryngoscope, 128(1), 84-90. https://doi.org/10.1002/lary.26704

Cutaneous squamous cell carcinoma of the lip : A population-based analysis. / Unsal, Aykut A; Unsal, Aylin B.; Henn, Tara E.; Baredes, Soly; Eloy, Jean Anderson.

In: Laryngoscope, Vol. 128, No. 1, 01.01.2018, p. 84-90.

Research output: Contribution to journalArticle

Unsal, AA, Unsal, AB, Henn, TE, Baredes, S & Eloy, JA 2018, 'Cutaneous squamous cell carcinoma of the lip: A population-based analysis', Laryngoscope, vol. 128, no. 1, pp. 84-90. https://doi.org/10.1002/lary.26704
Unsal, Aykut A ; Unsal, Aylin B. ; Henn, Tara E. ; Baredes, Soly ; Eloy, Jean Anderson. / Cutaneous squamous cell carcinoma of the lip : A population-based analysis. In: Laryngoscope. 2018 ; Vol. 128, No. 1. pp. 84-90.
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abstract = "Objectives/Hypothesis: The role of cumulative ultraviolet (UV) radiation in cutaneous squamous cell carcinoma of the lip (CSCCL) is well understood. This study seeks to evaluate overall survival as well as incidence and demographics across geographic regions, given differences in UV exposure across the United States. Study Design: Retrospective population-based analysis. Methods: A total of 14,901 CSCCL cases were identified as being from the West, Midwest, South, or Northeast, utilizing the Surveillance, Epidemiology, and End Results registry from 1973 to 2013. Demographics, stage of disease, and treatment modalities were compared among regions. Results: Of the CSCCL cases reported, 58.3{\%}, 24.5{\%}, 10.8{\%}, and 6.4{\%} originated from the West, Midwest, South, and Northeast, respectively. Patients most commonly presented with T1 tumors (81.3{\%}), and nodal and distant metastasis was rare for patients from all regions (3.1{\%} and 0.3{\%}, respectively). Patients with American Joint Committee on Cancer stage II and higher were most likely from the Northeast or South. Overall, most patients were treated with surgery monotherapy (89.5{\%}); however, surgical monotherapy was least commonly utilized in patients in the Northeast and South. Overall 5-year disease specific survival was measured at 94.7{\%}. Conclusion: Although areas of high UV index are implicated in increased morbidity and mortality due to CSCCL, this study indicates that a variety of factors play a role in CSCCL incidence and outcomes in the United States. The elderly and non-white populations were identified as poor prognostic demographic factors. Investigation detailing differences in CSCCL detection and treatment may aid in the identification of higher-risk populations. Level of Evidence: 4. Laryngoscope, 128:84–90, 2018.",
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