CXCR4 in epidermal keratinocytes: Crosstalk within the skin

Wendy B Bollag, William D Hill

Research output: Contribution to journalComment/debate

13 Citations (Scopus)

Abstract

In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.

Original languageEnglish (US)
Pages (from-to)2505-2508
Number of pages4
JournalJournal of Investigative Dermatology
Volume133
Issue number11
DOIs
StatePublished - Jan 1 2013

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Crosstalk
Keratinocytes
Skin
Interleukin-23
Basal Cell Carcinoma
Knockout Mice
Systemic Lupus Erythematosus
Wound Healing
Tumors
Cells
Ligands
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

CXCR4 in epidermal keratinocytes : Crosstalk within the skin. / Bollag, Wendy B; Hill, William D.

In: Journal of Investigative Dermatology, Vol. 133, No. 11, 01.01.2013, p. 2505-2508.

Research output: Contribution to journalComment/debate

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