TY - JOUR
T1 - CXCR4 in epidermal keratinocytes
T2 - Crosstalk within the skin
AU - Bollag, Wendy B.
AU - Hill, William D.
N1 - Funding Information:
This work was supported in part by a VA Research Career Scientist Award (WBB), VA Merit Awards (WBB and WDH), and National Institutes of Health award P01AG036675 (WBB and WDH). The contents of this article do not represent the views of the Department of Veterans Affairs or the United States Government.
PY - 2013/11
Y1 - 2013/11
N2 - In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
AB - In this issue, Takekoshi et al. investigated the role of CXCR4 in IL-23-induced keratinocyte hyperproliferation using an epidermal-specific knockout mouse model and found that CXCR4 limited keratinocyte proliferation. Some reports in the literature support this idea, whereas others contradict it; this disparity may be related to the differential roles of CXCR4 in various cell types or to a recently identified second receptor (CXCR7). Nevertheless, CXCR4 and its ligand SDF-1 have been implicated in skin wound healing, systemic lupus erythematosus, and basal cell carcinoma tumor angiogenesis. Further study is merited.
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U2 - 10.1038/jid.2013.271
DO - 10.1038/jid.2013.271
M3 - Comment/debate
C2 - 24129780
AN - SCOPUS:84886889790
SN - 0022-202X
VL - 133
SP - 2505
EP - 2508
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 11
ER -