Cyclical changes in susceptibility of a myeloma tumor (LPC-1) to immune destruction. I. Changes in reactivity with cytotoxic T lymphocytes and anti-H-2(d) sera

E. Celis, A. H. Hale, J. H. Russell, H. N. Eisen

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Abstract

One of six transplantable ascites tumors of BALB/c mice was found to become periodically resistant to cytotoxic T lymphocytes (CTL). About 12 days after LPC-1, a myeloma tumor, was transplanted it became resistant to lysis by allogenic CTL (anti-H-2(d)) and by CTL directed to trinitrophenyl groups or minor histocompatibility antigens. Susceptibility to lysis by all of these CTL was regained within 2 to 4 days after transfer of the resistant cells to a fresh BALB/c host. These changes were recurrent: in each transplantation cycle the early LPC-1 cells were susceptible and the late cells were resistant to CTL. Analyses with antisera (B10 anti-B10.D2) showed that the serologically recognized products of the H-2(d) haplotype were reduced about 10-fold on the LPC-1 cells that were resistant to CTL.

Original languageEnglish (US)
Pages (from-to)954-958
Number of pages5
JournalJournal of Immunology
Volume122
Issue number3
StatePublished - Dec 1 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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