Cyclosporine augments reactivity of isolated blood vessels

Fred S. Lamb, R. Clinton Webb

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Administration of cyclosporine (CS) as an immunosuppressive agent in clinical transplantation is associated with multiple side effects including nephrotoxicity and hypertension. These two effects could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investigate the ability of CS to augment contractile responsiveness in blood vessels from normotensive rats. Isometric force generation was measured in isolated tail arteries and portal veins. CS (8.3×10-6M) potentiated tail artery contractile responses to sympathetic nerve stimulation, exogenous norepinephrine, and increases in extracellular potassium concentration. Portal veins undergo spontaneous contractions which are related to the firing of calcium-driven action potentials in the smooth muscle cells. CS significantly increased the frequency of these spontaneous contractile events. These results suggest that components of CS toxicity may involve a direct action on vascular smooth muscle and/or on vascular adrenergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)2571-2578
Number of pages8
JournalLife sciences
Volume40
Issue number26
DOIs
StatePublished - Jun 29 1987

Fingerprint

Blood vessels
Cyclosporine
Blood Vessels
Portal Vein
Muscle
Tail
Arteries
Immunosuppressive Agents
Vascular Smooth Muscle
Synaptic Transmission
Adrenergic Agents
Action Potentials
Smooth Muscle Myocytes
Toxicity
Rats
Norepinephrine
Potassium
Blood
Transplantation
Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Cyclosporine augments reactivity of isolated blood vessels. / Lamb, Fred S.; Clinton Webb, R.

In: Life sciences, Vol. 40, No. 26, 29.06.1987, p. 2571-2578.

Research output: Contribution to journalArticle

Lamb, Fred S. ; Clinton Webb, R. / Cyclosporine augments reactivity of isolated blood vessels. In: Life sciences. 1987 ; Vol. 40, No. 26. pp. 2571-2578.
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