CYP2C9 allelic variants and frequencies in a pediatric sickle cell disease cohort: Implications for NSAIDs pharmacotherapy

Medicine & Life Sciences

• Cytochrome P-450 CYP2C9 100%
• Sickle Cell Anemia 82%
• Anti-Inflammatory Agents 55%
• Pediatrics 48%
• Drug Therapy 44%
• Gene Frequency 31%
• Alleles 31%
• Pharmaceutical Preparations 31%
• Population Genetics 13%
• Genetic Predisposition to Disease 10%
• Restriction Fragment Length Polymorphisms 10%
• African Americans 10%
• Pharmacokinetics 8%
• Genotype 7%
• Cohort Studies 7%
• Phenotype 6%
• Polymerase Chain Reaction 6%
• Safety 6%
• Pain 6%
• Mutation 6%
• DNA 6%
• Enzymes 5%

Chemical Compounds

• Nonsteroid Antiinflammatory Agent 86%
• Safety 21%
• Mutation 21%
• Metabolic 20%
• Pharmacological Metabolism 19%
• Pharmacokinetics 18%
• Length 14%
• Drug 13%