Cytochalasin selectively inhibits synthesis of a secretory protein, cellulose, in Achlya

Donovan Des S. Thomas, Marjorie Lutzac, Elias Kurian Manavathu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

IN an effort to elucidate the possible relationship between cytoplasmic streaming and secretion we used the male strain E87 of the water mould Achlya ambisexualis 1 . Cellulase secreted by Achlya presumably modifies the plasticity of the cellulosic walls of this fungus during morphogenesis 2 . Synthesis of this enzyme can be induced by the steroid hormone antheridiol, by amino acids 2 , or by shake induction (mechanical agitation) as reported here. In attempts to arrest streaming we used colchicine and vinblastine, which have been employed to disrupt microtubule function, and cytochalasins, whose reversible effects include inhibition of streaming 3 , of macromolecular secretion 4 , of uptake of small molecules such as glucose 5 , and destruction of microfilaments 6 .

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalNature
Volume249
Issue number5453
DOIs
StatePublished - Dec 1 1974

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Achlya
Cytochalasins
Cellulose
Fungi
Cytoplasmic Streaming
Vinblastine
Cellulase
Colchicine
Actin Cytoskeleton
Morphogenesis
Microtubules
Proteins
Steroids
Hormones
Amino Acids
Glucose
Water
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Cytochalasin selectively inhibits synthesis of a secretory protein, cellulose, in Achlya. / Thomas, Donovan Des S.; Lutzac, Marjorie; Manavathu, Elias Kurian.

In: Nature, Vol. 249, No. 5453, 01.12.1974, p. 140-142.

Research output: Contribution to journalArticle

Thomas, DDS, Lutzac, M & Manavathu, EK 1974, 'Cytochalasin selectively inhibits synthesis of a secretory protein, cellulose, in Achlya', Nature, vol. 249, no. 5453, pp. 140-142. https://doi.org/10.1038/249140a0
Thomas, Donovan Des S. ; Lutzac, Marjorie ; Manavathu, Elias Kurian. / Cytochalasin selectively inhibits synthesis of a secretory protein, cellulose, in Achlya. In: Nature. 1974 ; Vol. 249, No. 5453. pp. 140-142.
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