Cytokine-ion channel interactions in pulmonary inflammation

Jürg Hamacher, Yalda Hadizamani, Michèle Borgmann, Markus Mohaupt, Daniela Narcissa Männel, Ueli Moehrlen, Rudolf Lucas, Uz Stammberger

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The lungs conceptually represent a sponge that is interposed in series in the bodies' systemic circulation to take up oxygen and eliminate carbon dioxide. As such, it matches the huge surface areas of the alveolar epithelium to the pulmonary blood capillaries. The lung's constant exposure to the exterior necessitates a competent immune system, as evidenced by the association of clinical immunodeficiencies with pulmonary infections. From the in utero to the postnatal and adult situation, there is an inherent vital need to manage alveolar fluid reabsorption, be it postnatally, or in case of hydrostatic or permeability edema. Whereas a wealth of literature exists on the physiological basis of fluid and solute reabsorption by ion channels and water pores, only sparse knowledge is available so far on pathological situations, such as in microbial infection, acute lung injury or acute respiratory distress syndrome, and in the pulmonary reimplantation response in transplanted lungs. The aim of this review is to discuss alveolar liquid clearance in a selection of lung injury models, thereby especially focusing on cytokines and mediators that modulate ion channels. Inflammation is characterized by complex and probably time-dependent co-signaling, interactions between the involved cell types, as well as by cell demise and barrier dysfunction, which may not uniquely determine a clinical picture. This review, therefore, aims to give integrative thoughts and wants to foster the unraveling of unmet needs in future research.

Original languageEnglish (US)
Article number1644
JournalFrontiers in immunology
Volume8
Issue numberJAN
DOIs
StatePublished - Jan 4 2018

Fingerprint

Ion Channels
Pneumonia
Cytokines
Lung
Replantation
Acute Lung Injury
Adult Respiratory Distress Syndrome
Porifera
Lung Injury
Infection
Carbon Dioxide
Immune System
Permeability
Edema
Epithelium
Oxygen
Inflammation
Water

Keywords

  • Acute respiratory distress syndrome
  • Epithelial sodium channel
  • Ischemia-reperfusion injury
  • Lung transplantation
  • Na/K-ATPase
  • Pneumonia
  • TNF tip peptide
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M., Männel, D. N., Moehrlen, U., ... Stammberger, U. (2018). Cytokine-ion channel interactions in pulmonary inflammation. Frontiers in immunology, 8(JAN), [1644]. https://doi.org/10.3389/fimmu.2017.01644

Cytokine-ion channel interactions in pulmonary inflammation. / Hamacher, Jürg; Hadizamani, Yalda; Borgmann, Michèle; Mohaupt, Markus; Männel, Daniela Narcissa; Moehrlen, Ueli; Lucas, Rudolf; Stammberger, Uz.

In: Frontiers in immunology, Vol. 8, No. JAN, 1644, 04.01.2018.

Research output: Contribution to journalReview article

Hamacher, J, Hadizamani, Y, Borgmann, M, Mohaupt, M, Männel, DN, Moehrlen, U, Lucas, R & Stammberger, U 2018, 'Cytokine-ion channel interactions in pulmonary inflammation', Frontiers in immunology, vol. 8, no. JAN, 1644. https://doi.org/10.3389/fimmu.2017.01644
Hamacher J, Hadizamani Y, Borgmann M, Mohaupt M, Männel DN, Moehrlen U et al. Cytokine-ion channel interactions in pulmonary inflammation. Frontiers in immunology. 2018 Jan 4;8(JAN). 1644. https://doi.org/10.3389/fimmu.2017.01644
Hamacher, Jürg ; Hadizamani, Yalda ; Borgmann, Michèle ; Mohaupt, Markus ; Männel, Daniela Narcissa ; Moehrlen, Ueli ; Lucas, Rudolf ; Stammberger, Uz. / Cytokine-ion channel interactions in pulmonary inflammation. In: Frontiers in immunology. 2018 ; Vol. 8, No. JAN.
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