Cytokines in exertion-induced skeletal muscle injury

Joseph G. Cannon, Barbara A. St. Pierre

Research output: Contribution to journalReview article

129 Scopus citations

Abstract

Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. The biological actions and potential adaptive values of these cytokines through the course of muscle necrosis and regeneration will be described.

Original languageEnglish (US)
Pages (from-to)159-168
Number of pages10
JournalMolecular and Cellular Biochemistry
Volume179
Issue number1-2
DOIs
StatePublished - Jan 1 1998

Keywords

  • Cytokines
  • Exercise
  • Fibroblasts
  • Leukocyte
  • Necrosis
  • Neutrophils
  • Regeneration
  • Skeletal muscle
  • Tumour necrosis factor

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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