Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines

John H Crosby, W. C. Allsbrook, L. G. Koss, C. E. Bales, R. Witherington, P. A. Schulte, G. Hemstreet, K. Ringer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A total of 541 members of a cohort at increased risk for occupational bladder cancer underwent a 33-month program of screening with urine cytology. Selected workers received further urologic study with cystoscopy and bladder biopsies. Eight workers had positive or suspicious cytologic findings. Only one of the eight had a prior history of bladder cancer. Biopsies showed invasive carcinoma and/or nonpapillary carcinoma in situ in five workers in this group, severe atypia in one, and no significant abnormality in two. Of 56 workers who had atypical cytologic findings, 16 had bladder biopsies, which showed atypia of fat urothelium in 11, nonpapillary carcinoma in situ in one, noninfiltrating papillary carcinoma in one, and no significant abnormality in three. The cytologic detection of urothelial abnormalities often required more than a single specimen. Since the cohort in this study may develop more bladder cancers with the passage of time, continued follow-up is indicated.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalActa Cytologica
Volume35
Issue number3
StatePublished - Sep 19 1991

Fingerprint

Urinary Bladder Neoplasms
Amines
Carcinoma in Situ
Biopsy
Urinary Bladder
Urothelium
Neoplasms
Cystoscopy
Papillary Carcinoma
Cell Biology
Cohort Studies
Fats
Urine
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Crosby, J. H., Allsbrook, W. C., Koss, L. G., Bales, C. E., Witherington, R., Schulte, P. A., ... Ringer, K. (1991). Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines. Acta Cytologica, 35(3), 263-268.

Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines. / Crosby, John H; Allsbrook, W. C.; Koss, L. G.; Bales, C. E.; Witherington, R.; Schulte, P. A.; Hemstreet, G.; Ringer, K.

In: Acta Cytologica, Vol. 35, No. 3, 19.09.1991, p. 263-268.

Research output: Contribution to journalArticle

Crosby, JH, Allsbrook, WC, Koss, LG, Bales, CE, Witherington, R, Schulte, PA, Hemstreet, G & Ringer, K 1991, 'Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines', Acta Cytologica, vol. 35, no. 3, pp. 263-268.
Crosby JH, Allsbrook WC, Koss LG, Bales CE, Witherington R, Schulte PA et al. Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines. Acta Cytologica. 1991 Sep 19;35(3):263-268.
Crosby, John H ; Allsbrook, W. C. ; Koss, L. G. ; Bales, C. E. ; Witherington, R. ; Schulte, P. A. ; Hemstreet, G. ; Ringer, K. / Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines. In: Acta Cytologica. 1991 ; Vol. 35, No. 3. pp. 263-268.
@article{8e6e6c660252441a8fb6fae05eef184b,
title = "Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines",
abstract = "A total of 541 members of a cohort at increased risk for occupational bladder cancer underwent a 33-month program of screening with urine cytology. Selected workers received further urologic study with cystoscopy and bladder biopsies. Eight workers had positive or suspicious cytologic findings. Only one of the eight had a prior history of bladder cancer. Biopsies showed invasive carcinoma and/or nonpapillary carcinoma in situ in five workers in this group, severe atypia in one, and no significant abnormality in two. Of 56 workers who had atypical cytologic findings, 16 had bladder biopsies, which showed atypia of fat urothelium in 11, nonpapillary carcinoma in situ in one, noninfiltrating papillary carcinoma in one, and no significant abnormality in three. The cytologic detection of urothelial abnormalities often required more than a single specimen. Since the cohort in this study may develop more bladder cancers with the passage of time, continued follow-up is indicated.",
author = "Crosby, {John H} and Allsbrook, {W. C.} and Koss, {L. G.} and Bales, {C. E.} and R. Witherington and Schulte, {P. A.} and G. Hemstreet and K. Ringer",
year = "1991",
month = "9",
day = "19",
language = "English (US)",
volume = "35",
pages = "263--268",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "3",

}

TY - JOUR

T1 - Cytologic detection of urothelial cancer and other abnormalities in a cohort of workers exposed to aromatic amines

AU - Crosby, John H

AU - Allsbrook, W. C.

AU - Koss, L. G.

AU - Bales, C. E.

AU - Witherington, R.

AU - Schulte, P. A.

AU - Hemstreet, G.

AU - Ringer, K.

PY - 1991/9/19

Y1 - 1991/9/19

N2 - A total of 541 members of a cohort at increased risk for occupational bladder cancer underwent a 33-month program of screening with urine cytology. Selected workers received further urologic study with cystoscopy and bladder biopsies. Eight workers had positive or suspicious cytologic findings. Only one of the eight had a prior history of bladder cancer. Biopsies showed invasive carcinoma and/or nonpapillary carcinoma in situ in five workers in this group, severe atypia in one, and no significant abnormality in two. Of 56 workers who had atypical cytologic findings, 16 had bladder biopsies, which showed atypia of fat urothelium in 11, nonpapillary carcinoma in situ in one, noninfiltrating papillary carcinoma in one, and no significant abnormality in three. The cytologic detection of urothelial abnormalities often required more than a single specimen. Since the cohort in this study may develop more bladder cancers with the passage of time, continued follow-up is indicated.

AB - A total of 541 members of a cohort at increased risk for occupational bladder cancer underwent a 33-month program of screening with urine cytology. Selected workers received further urologic study with cystoscopy and bladder biopsies. Eight workers had positive or suspicious cytologic findings. Only one of the eight had a prior history of bladder cancer. Biopsies showed invasive carcinoma and/or nonpapillary carcinoma in situ in five workers in this group, severe atypia in one, and no significant abnormality in two. Of 56 workers who had atypical cytologic findings, 16 had bladder biopsies, which showed atypia of fat urothelium in 11, nonpapillary carcinoma in situ in one, noninfiltrating papillary carcinoma in one, and no significant abnormality in three. The cytologic detection of urothelial abnormalities often required more than a single specimen. Since the cohort in this study may develop more bladder cancers with the passage of time, continued follow-up is indicated.

UR - http://www.scopus.com/inward/record.url?scp=0025914622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025914622&partnerID=8YFLogxK

M3 - Article

C2 - 2042428

AN - SCOPUS:0025914622

VL - 35

SP - 263

EP - 268

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 3

ER -