Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients

T. Murayama, F. Jisaki, M. Ayata, D. Sakamuro, T. Hironaka, K. Hirai, N. Tsuchiya, K. Ito, T. Furukawa

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Synovial fluid from 20 patients with rheumatoid arthritis was analyzed to detect human cytomegalovirus (CMV) genomic material using polymerase chain reaction. Of 20 samples tested, 9 were positive for CMV by either ethidium bromide staining or Southern blotting. In contrast, CMV was detected in only 2 of 18 control patients with osteoarthritis. These results suggest an etiologic relationship between CMV and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalClinical and Experimental Rheumatology
Volume10
Issue number2
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients'. Together they form a unique fingerprint.

  • Cite this

    Murayama, T., Jisaki, F., Ayata, M., Sakamuro, D., Hironaka, T., Hirai, K., Tsuchiya, N., Ito, K., & Furukawa, T. (1992). Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients. Clinical and Experimental Rheumatology, 10(2), 161-164.