Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients

T. Murayama, F. Jisaki, M. Ayata, Daitoku Sakamuro, T. Hironaka, K. Hirai, N. Tsuchiya, K. Ito, T. Furukawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Synovial fluid from 20 patients with rheumatoid arthritis was analyzed to detect human cytomegalovirus (CMV) genomic material using polymerase chain reaction. Of 20 samples tested, 9 were positive for CMV by either ethidium bromide staining or Southern blotting. In contrast, CMV was detected in only 2 of 18 control patients with osteoarthritis. These results suggest an etiologic relationship between CMV and rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalClinical and Experimental Rheumatology
Volume10
Issue number2
StatePublished - Jan 1 1992
Externally publishedYes

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Synovial Fluid
Cytomegalovirus
Rheumatoid Arthritis
Genome
Polymerase Chain Reaction
Ethidium
Southern Blotting
Osteoarthritis
Staining and Labeling

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients. / Murayama, T.; Jisaki, F.; Ayata, M.; Sakamuro, Daitoku; Hironaka, T.; Hirai, K.; Tsuchiya, N.; Ito, K.; Furukawa, T.

In: Clinical and Experimental Rheumatology, Vol. 10, No. 2, 01.01.1992, p. 161-164.

Research output: Contribution to journalArticle

Murayama, T, Jisaki, F, Ayata, M, Sakamuro, D, Hironaka, T, Hirai, K, Tsuchiya, N, Ito, K & Furukawa, T 1992, 'Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients', Clinical and Experimental Rheumatology, vol. 10, no. 2, pp. 161-164.
Murayama, T. ; Jisaki, F. ; Ayata, M. ; Sakamuro, Daitoku ; Hironaka, T. ; Hirai, K. ; Tsuchiya, N. ; Ito, K. ; Furukawa, T. / Cytomegalovirus genomes demonstrates by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients. In: Clinical and Experimental Rheumatology. 1992 ; Vol. 10, No. 2. pp. 161-164.
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