Cytoskeletal mechanisms regulating vascular endothelial barrier function in response to acute lung injury

Anita Kása, Csilla Csortos, Alexander D. Verin

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Endothelial cells (EC) form a semi-permeable barrierbetween the interior space of blood vessels and theunderlying tissues. In acute lung injury (ALI) the EC barrier isweakened leading to increased vascular permeability. It iswidely accepted that EC barrier integrity is criticallydependent upon intact cytoskeletal structure and celljunctions. Edemagenic agonists, like thrombin or endotoxinlipopolysaccharide (LPS), induced cytoskeletal rearrangement,and EC contractile responses leading to disruption ofintercellular contacts and EC permeability increase. The highlyclinically-relevant cytoskeletal mechanisms of EC barrierdysfunction are currently under intense investigation and willbe described and discussed in the current review.

Original languageEnglish (US)
JournalTissue Barriers
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2015

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Keywords

  • Acute lung injury
  • Barrier function
  • Cytoskeleton
  • Endothelial junctions
  • Pulmonary endothelium
  • Thrombin

ASJC Scopus subject areas

  • Biochemistry
  • Histology
  • Cell Biology

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