Cytotoxic 4′-aminochalcones and related compounds

J. R. Dimmock, A. Jha, G. A. Zello, T. M. Allen, C. L. Santos, J. Balzarini, E. De Clercq, Elias Kurian Manavathu, J. P. Stables

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Abstract

A series of 4′-aminochalcones 1 and related maleamic acids 2 and Schiff bases 3 were designed and synthesized as candidate cytotoxic agents. The atomic charges on different atoms of representative compounds were calculated. Evaluation of the enones 1-3 against human Molt 4/C8 and CEM T-lymphocytes as well as murine P388 and L1210 leukemic cells revealed that approximately 40% of the IC50 values generated were less than 10 μM. In some cases cytotoxicity was correlated with the Hammett σ values of the aryl substituents and less frequently with the aryl Hansch π values. Evidence was obtained that in general these compounds displayed selective toxicity for certain malignant cells and were well tolerated in mice. This study has revealed various directions whereby the project may be amplified in the future with a view to finding compounds with increased cytotoxicity to tumour cells.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalPharmazie
Volume58
Issue number4
StatePublished - Apr 1 2003

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ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Dimmock, J. R., Jha, A., Zello, G. A., Allen, T. M., Santos, C. L., Balzarini, J., De Clercq, E., Manavathu, E. K., & Stables, J. P. (2003). Cytotoxic 4′-aminochalcones and related compounds. Pharmazie, 58(4), 227-232.