Abstract
The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O- β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6) -β-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β- D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)- 5-hydroxyheptane-3-O-β-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU-1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide) assay.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1287-1289 |
| Number of pages | 3 |
| Journal | Archives of Pharmacal Research |
| Volume | 31 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2008 |
| Externally published | Yes |
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Keywords
- Alnus japonica
- B16 melanoma cell
- Colorectal cell
- Cytotoxic activity
- Diarylheptanoid
- Gastric cancer cell
- Hepatoma cancer cell
ASJC Scopus subject areas
- Drug Discovery
- Molecular Medicine
- Organic Chemistry
Cite this
Cytotoxic activities of diarylheptanoids from Alnus japonica. / Choi, Sun Eun; Kim, Kwang Ho; Kwon, Joo Hee; Kim, Seung Bum; Kim, Ha Won; Lee, Min Won.
In: Archives of Pharmacal Research, Vol. 31, No. 10, 01.10.2008, p. 1287-1289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytotoxic activities of diarylheptanoids from Alnus japonica
AU - Choi, Sun Eun
AU - Kim, Kwang Ho
AU - Kwon, Joo Hee
AU - Kim, Seung Bum
AU - Kim, Ha Won
AU - Lee, Min Won
PY - 2008/10/1
Y1 - 2008/10/1
N2 - The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O- β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6) -β-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β- D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)- 5-hydroxyheptane-3-O-β-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU-1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide) assay.
AB - The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O- β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6) -β-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β- D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)- 5-hydroxyheptane-3-O-β-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU-1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide) assay.
KW - Alnus japonica
KW - B16 melanoma cell
KW - Colorectal cell
KW - Cytotoxic activity
KW - Diarylheptanoid
KW - Gastric cancer cell
KW - Hepatoma cancer cell
UR - http://www.scopus.com/inward/record.url?scp=55149122085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55149122085&partnerID=8YFLogxK
U2 - 10.1007/s12272-001-2108-z
DO - 10.1007/s12272-001-2108-z
M3 - Article
C2 - 18958419
AN - SCOPUS:55149122085
VL - 31
SP - 1287
EP - 1289
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
SN - 0253-6269
IS - 10
ER -