Cytotoxic activities of diarylheptanoids from Alnus japonica

Sun Eun Choi, Kwang Ho Kim, Joo Hee Kwon, Seung Bum Kim, Ha Won Kim, Min Won Lee

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The diarylheptanoids (1-10) 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O- β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (1), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-O-β-D-apiofuranosyl(1→6) -β-D-glucopyranoside (2), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-5-O-β- D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane (4), 1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (5), oregonin (6), hirsutanonol (7), hirsutenone (8), 1,7-bis-(3,4-dihydroxyphenyl)- 5-hydroxyheptane-3-O-β-D-xylopyranoside (9), and platyphylloside (10), isolated from the bark of Alnus japonica, were analyzed for their cytotoxic activities on various human and mouse cancer cell lines. The cytotoxic activities of these ten compounds were evaluated against murine B16 melanoma, human SNU-1 gastric cancer, human SNU-354 hepatoma cancer and human SNU-C4 colorectal cell lines. The diarylheptanoids showed potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cell when the cell viability was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazoliumbromide) assay.

Original languageEnglish (US)
Pages (from-to)1287-1289
Number of pages3
JournalArchives of Pharmacal Research
Volume31
Issue number10
DOIs
StatePublished - Oct 1 2008
Externally publishedYes

Keywords

  • Alnus japonica
  • B16 melanoma cell
  • Colorectal cell
  • Cytotoxic activity
  • Diarylheptanoid
  • Gastric cancer cell
  • Hepatoma cancer cell

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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