Cytotoxic effects of NaOCl on vital tissue

E. L. Pashley, N. L. Birdsong, K. Bowman, D. H. Pashley

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

The cytotoxicity of various dilutions of sodium hypochlorite was evaluated using three independent biological models. Dilutions as low as 1:1000 caused complete hemolysis of RBC's in vitro. Undiluted and 1:10 dilutions produced moderate to severe irritation to rabbit eyes which healed after 24 to 48 h. Intradermal injections of undiluted, 1:1, 1:2, and 1:4 dilutions of NaOCl produced skin ulcerations following intradermal injections. Although the use of 5% NaOCl for biomechanical preparation of root canals is a clinically acceptable and highly effective procedure, it must be used judiciously and with great caution to prevent it from reaching the periapex where it can elicit severe inflammatory reactions.

Original languageEnglish (US)
Pages (from-to)525-528
Number of pages4
JournalJournal of Endodontics
Volume11
Issue number12
DOIs
StatePublished - Dec 1985

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Intradermal Injections
Root Canal Preparation
Sodium Hypochlorite
Biological Models
Hemolysis
Rabbits
Skin
In Vitro Techniques

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Pashley, E. L., Birdsong, N. L., Bowman, K., & Pashley, D. H. (1985). Cytotoxic effects of NaOCl on vital tissue. Journal of Endodontics, 11(12), 525-528. https://doi.org/10.1016/S0099-2399(85)80197-7

Cytotoxic effects of NaOCl on vital tissue. / Pashley, E. L.; Birdsong, N. L.; Bowman, K.; Pashley, D. H.

In: Journal of Endodontics, Vol. 11, No. 12, 12.1985, p. 525-528.

Research output: Contribution to journalArticle

Pashley, EL, Birdsong, NL, Bowman, K & Pashley, DH 1985, 'Cytotoxic effects of NaOCl on vital tissue', Journal of Endodontics, vol. 11, no. 12, pp. 525-528. https://doi.org/10.1016/S0099-2399(85)80197-7
Pashley EL, Birdsong NL, Bowman K, Pashley DH. Cytotoxic effects of NaOCl on vital tissue. Journal of Endodontics. 1985 Dec;11(12):525-528. https://doi.org/10.1016/S0099-2399(85)80197-7
Pashley, E. L. ; Birdsong, N. L. ; Bowman, K. ; Pashley, D. H. / Cytotoxic effects of NaOCl on vital tissue. In: Journal of Endodontics. 1985 ; Vol. 11, No. 12. pp. 525-528.
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