D-penicillamine-induced myasthenia gravis: Diagnosis obscured by coexisting chronic obstructive pulmonary disease

H. M. Adelman, P. R. Winters, C. S. Mahan, Paul M Wallach

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

D-penicillamine, a drug used to treat rheumatoid arthritis, Wilson's disease, and cystinuria, can cause myasthenia gravis. Fortunately, the myasthenia typically resolves after discontinuation of the drug. The diagnosis may be missed if weakness is blamed on a patient's underlying disease(s), in particular, rheumatoid arthritis. Reported here are the cases of two patients with chronic obstructive lung disease who were taking D- penicillamine for rheumatoid arthritis, then experienced increasing respiratory failure. At first, their problem seemed to stem from chronic lung disease, but further evaluation revealed the cause of the hypoventilation to be D-penicillamine-induced myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)191-193
Number of pages3
JournalAmerican Journal of the Medical Sciences
Volume309
Issue number4
DOIs
StatePublished - Jan 1 1995

Fingerprint

Penicillamine
Myasthenia Gravis
Chronic Obstructive Pulmonary Disease
Rheumatoid Arthritis
Cystinuria
Hypoventilation
Hepatolenticular Degeneration
Respiratory Insufficiency
Pharmaceutical Preparations
Lung Diseases
Chronic Disease

Keywords

  • D-penicillamine, Adverse effects
  • Lung diseases
  • Myasthenia gravis
  • Obstructive
  • Respiratory insufficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

D-penicillamine-induced myasthenia gravis : Diagnosis obscured by coexisting chronic obstructive pulmonary disease. / Adelman, H. M.; Winters, P. R.; Mahan, C. S.; Wallach, Paul M.

In: American Journal of the Medical Sciences, Vol. 309, No. 4, 01.01.1995, p. 191-193.

Research output: Contribution to journalArticle

Adelman, H. M. ; Winters, P. R. ; Mahan, C. S. ; Wallach, Paul M. / D-penicillamine-induced myasthenia gravis : Diagnosis obscured by coexisting chronic obstructive pulmonary disease. In: American Journal of the Medical Sciences. 1995 ; Vol. 309, No. 4. pp. 191-193.
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