D-serine and serine racemase in the retina

Sylvia B Smith, Y. Ha, V. Ganapathy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent data suggest that D-serine is the endogenousligand for the 'glycine' binding site of theN-methyl-D-aspartate (NMDA) subtype ofglutamate receptor. This chapter reviews evidencethat this is the case, not only in brain, butalso in the retina. Information is provided documentingthe location of D-serine and serineracemase, in retinal Müller glial cells. The transportof D-serine by these cells is discussed. Newevidence demonstrating that D-serine and serineracemase are present in retinal neurons isprovided, along with data evaluating the effectsof excess D-serine on retinal neuronal viability.

Original languageEnglish (US)
Title of host publicationAmino Acids in Human Nutrition and Health
PublisherCABI Publishing
Pages137-149
Number of pages13
ISBN (Print)9781845937980
StatePublished - Nov 24 2011

Fingerprint

retina
serine
Serine
Retina
Retinal Neurons
D-Aspartic Acid
neuroglia
N-Methylaspartate
aspartic acid
glycine (amino acid)
Neuroglia
Glycine
Neurons
binding sites
Brain
neurons
Binding Sites
serine racemase
viability
brain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Agricultural and Biological Sciences(all)

Cite this

Smith, S. B., Ha, Y., & Ganapathy, V. (2011). D-serine and serine racemase in the retina. In Amino Acids in Human Nutrition and Health (pp. 137-149). CABI Publishing.

D-serine and serine racemase in the retina. / Smith, Sylvia B; Ha, Y.; Ganapathy, V.

Amino Acids in Human Nutrition and Health. CABI Publishing, 2011. p. 137-149.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smith, SB, Ha, Y & Ganapathy, V 2011, D-serine and serine racemase in the retina. in Amino Acids in Human Nutrition and Health. CABI Publishing, pp. 137-149.
Smith SB, Ha Y, Ganapathy V. D-serine and serine racemase in the retina. In Amino Acids in Human Nutrition and Health. CABI Publishing. 2011. p. 137-149
Smith, Sylvia B ; Ha, Y. ; Ganapathy, V. / D-serine and serine racemase in the retina. Amino Acids in Human Nutrition and Health. CABI Publishing, 2011. pp. 137-149
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