TY - JOUR
T1 - Daily variations in human plasma fluoride concentrations
AU - Cardoso, Vanessa E.S.
AU - Whitford, Gary M.
AU - Aoyama, Hiroshi
AU - Buzalaf, Marilia A.R.
N1 - Funding Information:
This study was supported by FAPESP (Grants 02/10361-6 and 02/10489-2 to the first and last authors, respectively).
PY - 2008/12
Y1 - 2008/12
N2 - This study investigated the variations in human plasma fluoride concentrations ([F]) and sought to determine the causes. Five subjects (27-33 years old) received a low-F diet during the 5 days of the study. Plasma samples and urine were collected every 3 h from 8 a.m. to 8 p.m. F, PTH, Ca and P were analyzed with the electrode, by chemiluminescence, AAS and colorimetry, respectively. A trend for the plasma [F] was found. The peak [F], 0.55 ± 0.11 μmol L-1, occurred at 11 a.m. and the lowest [F], 0.50 ± 0.06 μmol L-1 occurred between 5 and 8 p.m. Plasma [F] were positively correlated with urinary F excretion rates and with serum PTH levels, but not with the Ca or P levels. Serum PTH levels were positively correlated with urinary F excretion rates and negatively correlated with plasma Ca. The results suggest that the renal system seems to control the daily fluctuations in plasma [F].
AB - This study investigated the variations in human plasma fluoride concentrations ([F]) and sought to determine the causes. Five subjects (27-33 years old) received a low-F diet during the 5 days of the study. Plasma samples and urine were collected every 3 h from 8 a.m. to 8 p.m. F, PTH, Ca and P were analyzed with the electrode, by chemiluminescence, AAS and colorimetry, respectively. A trend for the plasma [F] was found. The peak [F], 0.55 ± 0.11 μmol L-1, occurred at 11 a.m. and the lowest [F], 0.50 ± 0.06 μmol L-1 occurred between 5 and 8 p.m. Plasma [F] were positively correlated with urinary F excretion rates and with serum PTH levels, but not with the Ca or P levels. Serum PTH levels were positively correlated with urinary F excretion rates and negatively correlated with plasma Ca. The results suggest that the renal system seems to control the daily fluctuations in plasma [F].
KW - Biological rhythm
KW - Fluoride
KW - PTH
KW - Plasma
KW - Renal system
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U2 - 10.1016/j.jfluchem.2008.09.008
DO - 10.1016/j.jfluchem.2008.09.008
M3 - Article
AN - SCOPUS:56049099252
SN - 0022-1139
VL - 129
SP - 1193
EP - 1198
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 12
ER -