TY - JOUR
T1 - Dalbavancin
T2 - A novel antimicrobial
AU - Chen, A. Y.
AU - Zervos, M. J.
AU - Vazquez, J. A.
PY - 2007/5
Y1 - 2007/5
N2 - The increasing incidence of serious infections because of Gram-positive pathogens and the rising cost in parenteral administration of antimicrobials has inspired the development of a novel antibiotic. Dalbavancin is the first once a week antibiotic with activity against a broad range of Gram-positive pathogens. A large multicentre, pivotal, Phase III clinical trial, which included 854 patients with complicated skin and skin structure infections, compared 1-2 doses of dalbavancin vs. linezolid. The results demonstrated non-inferiority and a comparable safety profile. With its unique pharmacokinetic profile, ease of use and excellent safety profile, dalbavancin should provide a valuable addition to the armamentarium used to treat infections because of Gram-positive cocci.
AB - The increasing incidence of serious infections because of Gram-positive pathogens and the rising cost in parenteral administration of antimicrobials has inspired the development of a novel antibiotic. Dalbavancin is the first once a week antibiotic with activity against a broad range of Gram-positive pathogens. A large multicentre, pivotal, Phase III clinical trial, which included 854 patients with complicated skin and skin structure infections, compared 1-2 doses of dalbavancin vs. linezolid. The results demonstrated non-inferiority and a comparable safety profile. With its unique pharmacokinetic profile, ease of use and excellent safety profile, dalbavancin should provide a valuable addition to the armamentarium used to treat infections because of Gram-positive cocci.
UR - http://www.scopus.com/inward/record.url?scp=34247092376&partnerID=8YFLogxK
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U2 - 10.1111/j.1742-1241.2007.01318.x
DO - 10.1111/j.1742-1241.2007.01318.x
M3 - Review article
C2 - 17362476
AN - SCOPUS:34247092376
SN - 1368-5031
VL - 61
SP - 853
EP - 863
JO - International Journal of Clinical Practice
JF - International Journal of Clinical Practice
IS - 5
ER -