Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress

Ravirajsinh N. Jadeja, Nathalie H. Urrunaga, Daniel Ahmad, Sandeep Khurana

Research output: Contribution to journalArticle

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Abstract

We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.

Original languageEnglish (US)
Pages (from-to)405-409
Number of pages5
JournalData in Brief
Volume6
DOIs
StatePublished - Mar 1 2016

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Keywords

  • Catalase
  • Muscarinic receptors
  • Oxidative stress

ASJC Scopus subject areas

  • General

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