TY - JOUR
T1 - Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
AU - Jadeja, Ravirajsinh N.
AU - Urrunaga, Nathalie H.
AU - Ahmad, Daniel
AU - Khurana, Sandeep
PY - 2016/3/1
Y1 - 2016/3/1
N2 - We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
AB - We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
KW - Catalase
KW - Muscarinic receptors
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84951081492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951081492&partnerID=8YFLogxK
U2 - 10.1016/j.dib.2015.12.025
DO - 10.1016/j.dib.2015.12.025
M3 - Article
AN - SCOPUS:84951081492
VL - 6
SP - 405
EP - 409
JO - Data in Brief
JF - Data in Brief
SN - 2352-3409
ER -