TY - JOUR
T1 - Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
AU - Jadeja, Ravirajsinh N.
AU - Urrunaga, Nathalie H.
AU - Ahmad, Daniel
AU - Khurana, Sandeep
N1 - Funding Information:
This work was supported by the NIH ( K08DK081479 ) and the Department of Medicine at the Medical College of Georgia. We thank Dr. Michael Duncan (Medical College of Georgia) for providing AML12 cells, and Dr. Jürgen Wess (NIDDK) for providing Chrm1−/− and wild type mice.
Publisher Copyright:
© 2015 The Authors.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
AB - We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H2O2-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H2O2-treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
KW - Catalase
KW - Muscarinic receptors
KW - Oxidative stress
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U2 - 10.1016/j.dib.2015.12.025
DO - 10.1016/j.dib.2015.12.025
M3 - Article
AN - SCOPUS:84951081492
VL - 6
SP - 405
EP - 409
JO - Data in Brief
JF - Data in Brief
SN - 2352-3409
ER -