Deciphering the pathways of life and death

Honglin Li, Junying Yuan

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Caspase recruitment and oligomerization mediated by adaptor proteins constitute a basic mechanism of caspase activation. The complex phenotypes of the caspase knockout mice indicate that multiple mechanisms of caspase activation operate in parallel and that death signal transduction pathways are both cell-type and stimulus specific. The BH3-domain-containing pro-apototic members of Bcl-2 family may be one of the critical links between the initial death signals and the central machinery of apoptosis.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume11
Issue number2
DOIs
StatePublished - Apr 1 1999
Externally publishedYes

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Caspases
Knockout Mice
Signal Transduction
Apoptosis
Phenotype
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Deciphering the pathways of life and death. / Li, Honglin; Yuan, Junying.

In: Current Opinion in Cell Biology, Vol. 11, No. 2, 01.04.1999, p. 261-266.

Research output: Contribution to journalArticle

Li, Honglin ; Yuan, Junying. / Deciphering the pathways of life and death. In: Current Opinion in Cell Biology. 1999 ; Vol. 11, No. 2. pp. 261-266.
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