Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men

Rachel Lampert, J. Douglas Bremner, Shaoyong Su, Andrew Miller, Forrester Lee, Faiz Cheema, Jack Goldberg, Viola Vaccarino

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Background: Many traditional risk factors for coronary artery disease (CAD) are associated with altered autonomic function. Inflammation may provide a link between risk factors, autonomic dysfunction, and CAD. We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measured by C-reactive protein (CRP) and interleukin-6 (IL-6). Methods: We examined 264 middle-aged male twins free of symptomatic CAD. All underwent ambulatory electrocardiogram monitoring and 24-hour ultra low, very low, low, and high-frequency power were calculated using power spectral analysis. C-reactive protein and IL-6 were measured, and risk factors including age, smoking, hypertension, lipids, diabetes, body mass index (BMI), depression, and physical activity were assessed. Results: Physical activity, BMI, high-density lipoprotein cholesterol, smoking, depression, and hypertension were directly associated with CRP and IL-6 and inversely associated with one or more HRV variables. There was a graded inverse relationship between all HRV parameters (except high frequency) and CRP and IL-6. After adjustment for age, BMI, activity, high-density lipoprotein, smoking, hypertension, depression, and diabetes, ultra low frequency and very low frequency remained significant predictors of CRP (P < .01). Conclusions: C-reactive protein is associated with decreased HRV, even after controlling for traditional CAD risk factors. Autonomic dysregulation leading to inflammation may represent one pathway through which traditional risk factors promote development of CAD.

Original languageEnglish (US)
Pages (from-to)759.e1-759.e7
JournalAmerican Heart Journal
Volume156
Issue number4
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

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C-Reactive Protein
Heart Rate
Coronary Artery Disease
Inflammation
Interleukin-6
Body Mass Index
Smoking
Depression
Hypertension
Exercise
Ambulatory Monitoring
HDL Lipoproteins
HDL Cholesterol
Electrocardiography
Lipids
Power (Psychology)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lampert, R., Bremner, J. D., Su, S., Miller, A., Lee, F., Cheema, F., ... Vaccarino, V. (2008). Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. American Heart Journal, 156(4), 759.e1-759.e7. https://doi.org/10.1016/j.ahj.2008.07.009

Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. / Lampert, Rachel; Bremner, J. Douglas; Su, Shaoyong; Miller, Andrew; Lee, Forrester; Cheema, Faiz; Goldberg, Jack; Vaccarino, Viola.

In: American Heart Journal, Vol. 156, No. 4, 01.01.2008, p. 759.e1-759.e7.

Research output: Contribution to journalArticle

Lampert, R, Bremner, JD, Su, S, Miller, A, Lee, F, Cheema, F, Goldberg, J & Vaccarino, V 2008, 'Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men', American Heart Journal, vol. 156, no. 4, pp. 759.e1-759.e7. https://doi.org/10.1016/j.ahj.2008.07.009
Lampert, Rachel ; Bremner, J. Douglas ; Su, Shaoyong ; Miller, Andrew ; Lee, Forrester ; Cheema, Faiz ; Goldberg, Jack ; Vaccarino, Viola. / Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. In: American Heart Journal. 2008 ; Vol. 156, No. 4. pp. 759.e1-759.e7.
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