Decreased thrombogenicity of vascular prostheses following gas denucleation by hydrostatic pressure

Christopher P. Demas, Richard Vann, Edmond Ritter, Richard S. Sepka, Bruce Klitzman, William J. Barwick

Research output: Contribution to journalArticle

11 Scopus citations


The high rate of thrombosis of 1.0-mm polytetrafluoroethylene (PTFE) grafts has limited their use in microvascular surgery. One possible reason for this is the blood-gas interface due to entrapped air in the interstices. The present study examines the effect on patency rates of elimination of this blood-gas interface by high pressurization. Comparing pressurized and nonpressurized grafts in the same animals showed a patency rate of 100 percent at 7 days for treated grafts, while the control (nonpressurized) grafts had all clotted by 1 hour. The implications for microvascular surgery as well as vascular surgery in general are discussed.

Original languageEnglish (US)
Pages (from-to)1042-1045
Number of pages4
JournalPlastic and reconstructive surgery
Issue number6
Publication statusPublished - Dec 1988
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

Cite this