Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

John Sidney, Howard M. Grey, Scott Southwood, Esteban Celis, Peggy A. Wentworth, Marie France Del Guercio, Ralph T. Kubo, Robert W. Chesnut, Alessandro Sette

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

An HLA-A3-like supertype (minimally comprised of products from the HLA class I alleles A3, A11, A31, A*3301, and A*6801) has been defined on the basis of (a) structural similarities in the antigen-binding groove, (b) shared main anchor peptide-binding motifs, (c) the identification of peptides cross-reacting with most or all of these molecules, and (d) the definition of an A3-like supermotif that efficiently predicts highly cross-reactive peptides. Detailed secondary anchor maps for A3, A11, A31, A*3301, and A*6801 are also described. The biologic relevance of the A3-like supertype is indicated by the fact that high frequencies of the A3-like supertype alleles are conserved in all major ethnic groups. Because A3-like supertype alleles are found in most major HLA evolutionary lineages, possibly a reflection of common ancestry, the A3-like supermotif might in fact represent a primeval human HLA class I peptide-binding specificity. It is also possible that these phenomena might be related to optimal exploitation of the peptide specificity by human TAP molecules. The grouping of HLA alleles into supertypes on the basis of their overlapping peptide-binding repertoires represents an alternative to serologic or phylogenetic classification.

Original languageEnglish (US)
Pages (from-to)79-93
Number of pages15
JournalHuman Immunology
Volume45
Issue number2
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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HLA-A3 Antigen
Peptides
Alleles
Ethnic Groups
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules. / Sidney, John; Grey, Howard M.; Southwood, Scott; Celis, Esteban; Wentworth, Peggy A.; Del Guercio, Marie France; Kubo, Ralph T.; Chesnut, Robert W.; Sette, Alessandro.

In: Human Immunology, Vol. 45, No. 2, 01.01.1996, p. 79-93.

Research output: Contribution to journalArticle

Sidney, J, Grey, HM, Southwood, S, Celis, E, Wentworth, PA, Del Guercio, MF, Kubo, RT, Chesnut, RW & Sette, A 1996, 'Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules', Human Immunology, vol. 45, no. 2, pp. 79-93. https://doi.org/10.1016/0198-8859(95)00173-5
Sidney, John ; Grey, Howard M. ; Southwood, Scott ; Celis, Esteban ; Wentworth, Peggy A. ; Del Guercio, Marie France ; Kubo, Ralph T. ; Chesnut, Robert W. ; Sette, Alessandro. / Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules. In: Human Immunology. 1996 ; Vol. 45, No. 2. pp. 79-93.
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