Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer

Lily Lou, Clare Bergson, William Mcginnis

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

esophageal ganglion of the embryonic central nervous system. This Neural autoregulatory enhancer (NAE) maps in the large Dfd intron just upstream of the homeobox exon and requires Dfd protein function for its full activity. A 608 bp NAE subfragment retains regulatory function that is principally localized in the subesophageal ganglion. This small region of the Drosophila melanogaster genome contains numerous blocks of sequence conservation with a comparable region from the Dfd locus of D.hydei. A pair of conserved blocks of NAE sequence match a Dfd protein binding site in the epidermal autoregulatory element, while another conserved sequence motif is repeated multiple times within the 608 bp subelement.

Original languageEnglish (US)
Pages (from-to)3481-3487
Number of pages7
JournalNucleic Acids Research
Volume23
Issue number17
DOIs
StatePublished - Sep 11 1995

Fingerprint

Ganglia
Drosophila
Central Nervous System
Conserved Sequence
Homeobox Genes
Drosophila melanogaster
Protein Binding
Introns
Exons
Binding Sites
Genome
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. / Lou, Lily; Bergson, Clare; Mcginnis, William.

In: Nucleic Acids Research, Vol. 23, No. 17, 11.09.1995, p. 3481-3487.

Research output: Contribution to journalArticle

@article{0855bd91d42e4095b99b911c4b359f13,
title = "Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer",
abstract = "esophageal ganglion of the embryonic central nervous system. This Neural autoregulatory enhancer (NAE) maps in the large Dfd intron just upstream of the homeobox exon and requires Dfd protein function for its full activity. A 608 bp NAE subfragment retains regulatory function that is principally localized in the subesophageal ganglion. This small region of the Drosophila melanogaster genome contains numerous blocks of sequence conservation with a comparable region from the Dfd locus of D.hydei. A pair of conserved blocks of NAE sequence match a Dfd protein binding site in the epidermal autoregulatory element, while another conserved sequence motif is repeated multiple times within the 608 bp subelement.",
author = "Lily Lou and Clare Bergson and William Mcginnis",
year = "1995",
month = "9",
day = "11",
doi = "10.1093/nar/23.17.3481",
language = "English (US)",
volume = "23",
pages = "3481--3487",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "17",

}

TY - JOUR

T1 - Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer

AU - Lou, Lily

AU - Bergson, Clare

AU - Mcginnis, William

PY - 1995/9/11

Y1 - 1995/9/11

N2 - esophageal ganglion of the embryonic central nervous system. This Neural autoregulatory enhancer (NAE) maps in the large Dfd intron just upstream of the homeobox exon and requires Dfd protein function for its full activity. A 608 bp NAE subfragment retains regulatory function that is principally localized in the subesophageal ganglion. This small region of the Drosophila melanogaster genome contains numerous blocks of sequence conservation with a comparable region from the Dfd locus of D.hydei. A pair of conserved blocks of NAE sequence match a Dfd protein binding site in the epidermal autoregulatory element, while another conserved sequence motif is repeated multiple times within the 608 bp subelement.

AB - esophageal ganglion of the embryonic central nervous system. This Neural autoregulatory enhancer (NAE) maps in the large Dfd intron just upstream of the homeobox exon and requires Dfd protein function for its full activity. A 608 bp NAE subfragment retains regulatory function that is principally localized in the subesophageal ganglion. This small region of the Drosophila melanogaster genome contains numerous blocks of sequence conservation with a comparable region from the Dfd locus of D.hydei. A pair of conserved blocks of NAE sequence match a Dfd protein binding site in the epidermal autoregulatory element, while another conserved sequence motif is repeated multiple times within the 608 bp subelement.

UR - http://www.scopus.com/inward/record.url?scp=0029052595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029052595&partnerID=8YFLogxK

U2 - 10.1093/nar/23.17.3481

DO - 10.1093/nar/23.17.3481

M3 - Article

C2 - 7567459

AN - SCOPUS:0029052595

VL - 23

SP - 3481

EP - 3487

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 17

ER -