Delineation of gastric cancer subtypes by co-regulated expression of receptor tyrosine kinases and chemosensitivity genes

Shu Chun Li, Rong Ma, Jian Zhong Wu, Xia Xiao, Wei Wu, Gang Li, Bo Chen, Ashok Kumar Sharma, Shan Bai, Bo Ying Dun, Jin-Xiong She, Jin Hai Tang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Chemotherapy plays a key role in improving disease-free survival and overall survival of gastric cancer (GC); however, response rates are variable and a non-negligible proportion of patients undergo toxic and costly chemotherapeutic regimens without a survival benefit. Several studies have shown the existence of GC subtypes which may predict survival and respond differently to chemotherapy. It is also known that the expression level of chemotherapy-related and target therapy-related genes correlates with response to specific antitumor drugs. Nevertheless, these genes have not been considered jointly to define GC subtypes. In this study, we evaluated seven genes known to influence chemotherapeutic response (ERCC1, BRCA1, RRM1, TUBB3, STMN1, TYMS and TOP2A) and five receptor tyrosine kinases (RTKs) (EGFR, ERBB2, PDGFRB, VEGFR1 and VEGFR2). We demonstrate significant heterogeneity of gene expression among GC patients and identified four GC subtypes using the expression profiles of eight genes in two co-regulation groups: chemosensitivity (BRCA1, STMN1, TYMS andTOP2A) and RTKs (EGFR, PDGFRB, VEGFR1 and VEGFR2). The results are of immediate translational value regarding GC diagnostics and therapeutics, as many of these genes are curently widely used in relevant clinical testing.

Original languageEnglish (US)
Pages (from-to)1429-1439
Number of pages11
JournalAmerican Journal of Translational Research
Volume7
Issue number8
StatePublished - Sep 11 2015

Keywords

  • Chemotherapy
  • Co-regulation
  • Gastric cancer
  • Gene expression

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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  • Cite this

    Li, S. C., Ma, R., Wu, J. Z., Xiao, X., Wu, W., Li, G., Chen, B., Sharma, A. K., Bai, S., Dun, B. Y., She, J-X., & Tang, J. H. (2015). Delineation of gastric cancer subtypes by co-regulated expression of receptor tyrosine kinases and chemosensitivity genes. American Journal of Translational Research, 7(8), 1429-1439.