Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper

Potential links between circadian mechanisms and obesity?

J. M. Gimble, A. A. Ptitsyn, B. C. Goh, T. Hebert, G. Yu, X. Wu, S. Zvonic, Xing Ming Shi, Z. E. Floyd

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

As the obesity pandemic has accelerated, investigators have begun to explore alternative mechanisms linking circadian biology and sleep to adipose tissue metabolism and obesity. This manuscript reviews recent findings in murine and human models demonstrating the oscillatory expression of the mRNAs encoding the core circadian regulatory proteins in adipose tissue. Comparative transcriptomic analyses of circadian oscillating genes have been used to identify the 'delta sleep-inducing peptide immunoreactor', also known as 'glucocorticoid-induced leucine zipper (GILZ)', as a potential link in this chain. The GILZ gene has been found to differentially regulate stromal stem cell adipogenic and osteogenic differentiation in a reciprocal manner. In adipose and other metabolically active tissues, the circadian oscillation of GILZ expression is subject to entrainment by external stimuli. Together, these observations suggest that GILZ is an attractive candidate for future studies evaluating the role of circadian mechanisms in adipose tissue physiology and pathology.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalObesity Reviews
Volume10
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 1 2009

Fingerprint

Delta Sleep-Inducing Peptide
Leucine Zippers
Glucocorticoids
Obesity
Adipose Tissue
Pandemics
Stromal Cells
Genes
Sleep
Stem Cells
Research Personnel
Pathology
Messenger RNA
Proteins

Keywords

  • Circadian
  • Delta sleep-inducing peptide
  • Glucocorticoid-induced leucine zipper
  • Obesity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper : Potential links between circadian mechanisms and obesity? / Gimble, J. M.; Ptitsyn, A. A.; Goh, B. C.; Hebert, T.; Yu, G.; Wu, X.; Zvonic, S.; Shi, Xing Ming; Floyd, Z. E.

In: Obesity Reviews, Vol. 10, No. SUPPL. 2, 01.11.2009, p. 46-51.

Research output: Contribution to journalReview article

Gimble, J. M. ; Ptitsyn, A. A. ; Goh, B. C. ; Hebert, T. ; Yu, G. ; Wu, X. ; Zvonic, S. ; Shi, Xing Ming ; Floyd, Z. E. / Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper : Potential links between circadian mechanisms and obesity?. In: Obesity Reviews. 2009 ; Vol. 10, No. SUPPL. 2. pp. 46-51.
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