Delusional Infestation in Parkinson's Disease

Jennie L. Davis, Julie A. Kurek, Kapil D. Sethi, John C. Morgan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Delusional infestation (DI), a form of psychosis, has rarely been reported in patients with Parkinson disease (PD). The clinical presentation and successful treatment of DI is illustrated through 5 cases. Each patient developed DI during treatment for moderate to advanced Parkinson's disease, and only 2 had cognitive impairment. Two patients were on monotherapy: 1 on a dopamine agonist and the other on trihexyphenidyl. Three patients were receiving complex combination therapy with 2 to 5 different anti-Parkinsonian medications at the onset of their delusion. Selective discontinuation or reduction of these medications was key to the resolution of DI in each patient. Although the medication adjustments differed, the changes resulted in the reduction of anticholinergic effects or extracellular striatal dopamine levels. This series emphasizes the clinical features and management strategies for this disruptive form of psychosis in patients with PD.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalMovement Disorders Clinical Practice
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Parkinson Disease
Psychotic Disorders
Trihexyphenidyl
Social Adjustment
Corpus Striatum
Delusions
Dopamine Agonists
Cholinergic Antagonists
Dopamine
Therapeutics

Keywords

  • Parkinson's disease
  • delusional infestation
  • delusional parasitosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Delusional Infestation in Parkinson's Disease. / Davis, Jennie L.; Kurek, Julie A.; Sethi, Kapil D.; Morgan, John C.

In: Movement Disorders Clinical Practice, Vol. 4, No. 1, 01.01.2017, p. 111-115.

Research output: Contribution to journalArticle

Davis, Jennie L. ; Kurek, Julie A. ; Sethi, Kapil D. ; Morgan, John C. / Delusional Infestation in Parkinson's Disease. In: Movement Disorders Clinical Practice. 2017 ; Vol. 4, No. 1. pp. 111-115.
@article{2fa2b0f82fd947adbffac7ccfee396b3,
title = "Delusional Infestation in Parkinson's Disease",
abstract = "Delusional infestation (DI), a form of psychosis, has rarely been reported in patients with Parkinson disease (PD). The clinical presentation and successful treatment of DI is illustrated through 5 cases. Each patient developed DI during treatment for moderate to advanced Parkinson's disease, and only 2 had cognitive impairment. Two patients were on monotherapy: 1 on a dopamine agonist and the other on trihexyphenidyl. Three patients were receiving complex combination therapy with 2 to 5 different anti-Parkinsonian medications at the onset of their delusion. Selective discontinuation or reduction of these medications was key to the resolution of DI in each patient. Although the medication adjustments differed, the changes resulted in the reduction of anticholinergic effects or extracellular striatal dopamine levels. This series emphasizes the clinical features and management strategies for this disruptive form of psychosis in patients with PD.",
keywords = "Parkinson's disease, delusional infestation, delusional parasitosis",
author = "Davis, {Jennie L.} and Kurek, {Julie A.} and Sethi, {Kapil D.} and Morgan, {John C.}",
year = "2017",
month = "1",
day = "1",
doi = "10.1002/mdc3.12352",
language = "English (US)",
volume = "4",
pages = "111--115",
journal = "Movement Disorders Clinical Practice",
issn = "2330-1619",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Delusional Infestation in Parkinson's Disease

AU - Davis, Jennie L.

AU - Kurek, Julie A.

AU - Sethi, Kapil D.

AU - Morgan, John C.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Delusional infestation (DI), a form of psychosis, has rarely been reported in patients with Parkinson disease (PD). The clinical presentation and successful treatment of DI is illustrated through 5 cases. Each patient developed DI during treatment for moderate to advanced Parkinson's disease, and only 2 had cognitive impairment. Two patients were on monotherapy: 1 on a dopamine agonist and the other on trihexyphenidyl. Three patients were receiving complex combination therapy with 2 to 5 different anti-Parkinsonian medications at the onset of their delusion. Selective discontinuation or reduction of these medications was key to the resolution of DI in each patient. Although the medication adjustments differed, the changes resulted in the reduction of anticholinergic effects or extracellular striatal dopamine levels. This series emphasizes the clinical features and management strategies for this disruptive form of psychosis in patients with PD.

AB - Delusional infestation (DI), a form of psychosis, has rarely been reported in patients with Parkinson disease (PD). The clinical presentation and successful treatment of DI is illustrated through 5 cases. Each patient developed DI during treatment for moderate to advanced Parkinson's disease, and only 2 had cognitive impairment. Two patients were on monotherapy: 1 on a dopamine agonist and the other on trihexyphenidyl. Three patients were receiving complex combination therapy with 2 to 5 different anti-Parkinsonian medications at the onset of their delusion. Selective discontinuation or reduction of these medications was key to the resolution of DI in each patient. Although the medication adjustments differed, the changes resulted in the reduction of anticholinergic effects or extracellular striatal dopamine levels. This series emphasizes the clinical features and management strategies for this disruptive form of psychosis in patients with PD.

KW - Parkinson's disease

KW - delusional infestation

KW - delusional parasitosis

UR - http://www.scopus.com/inward/record.url?scp=85041300032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041300032&partnerID=8YFLogxK

U2 - 10.1002/mdc3.12352

DO - 10.1002/mdc3.12352

M3 - Article

AN - SCOPUS:85041300032

VL - 4

SP - 111

EP - 115

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

SN - 2330-1619

IS - 1

ER -