Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Sergei A Kirov, Kristen M. Harris

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

Original languageEnglish (US)
Pages (from-to)878-883
Number of pages6
JournalNature Neuroscience
Volume2
Issue number10
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

Fingerprint

Dendrites
Synaptic Transmission
Synapses
Sodium Channel Blockers
Neurons
Excitatory Amino Acid Antagonists
Pyramidal Cells
Calcium Channel Blockers
Magnesium
Spine
Calcium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated. / Kirov, Sergei A; Harris, Kristen M.

In: Nature Neuroscience, Vol. 2, No. 10, 01.10.1999, p. 878-883.

Research output: Contribution to journalArticle

@article{be5969bbcf564a2db9ad782b65436a66,
title = "Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated",
abstract = "Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.",
author = "Kirov, {Sergei A} and Harris, {Kristen M.}",
year = "1999",
month = "10",
day = "1",
doi = "10.1038/13178",
language = "English (US)",
volume = "2",
pages = "878--883",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

AU - Kirov, Sergei A

AU - Harris, Kristen M.

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

AB - Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

UR - http://www.scopus.com/inward/record.url?scp=0033306744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033306744&partnerID=8YFLogxK

U2 - 10.1038/13178

DO - 10.1038/13178

M3 - Article

VL - 2

SP - 878

EP - 883

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 10

ER -