Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Sergei A. Kirov, Kristen M. Harris

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic transmission was blocked with glutamate receptor antagonists, sodium and calcium channel blockers and/or a nominally calcium-free medium with high magnesium. In other slices, synapses were activated with low-frequency control stimulation or repeated tetanic stimulation. In slices with blocked synaptic transmission, dendrites were spinier than in either of the activated states. Thus, mature neurons can increase their numbers of spines, possibly compensating for lost synaptic activity.

Original languageEnglish (US)
Pages (from-to)878-883
Number of pages6
JournalNature Neuroscience
Volume2
Issue number10
DOIs
StatePublished - Oct 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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