Dendritic cells: A specialized complex system of antigen presenting cells

Levi H.C. Makala, Hideyuki Nagasawa

Research output: Contribution to journalReview article

16 Scopus citations


The dendritic cell (DC) network is a specialized system for presenting antigen to naive or quiescent T cells, and consequently plays a central role in the induction of T cell and B cell immunity in vivo. Despite considerable achievements in the last ten years, in our understanding of how DC induce and regulate immune responses, much remains to be learned about this complex system of cells. The history and current status of DC termed "directors of the immune system orchestra" is reviewed. The present understanding of DC cell biology, function and use, taking into account their complexity is discussed.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalJournal of Veterinary Medical Science
Issue number3
StatePublished - Mar 1 2002


  • Classification
  • Dendritic cell
  • Feature
  • Ontogeny

ASJC Scopus subject areas

  • veterinary(all)

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