Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks

Sook Jin Son, Jessica Andrea Filosa, Evgeniy S. Potapenko, Vinicia Campana Biancardi, Hong Zheng, Kaushik P. Patel, Vicky A. Tobin, Mike Ludwig, Javier Eduardo Stern

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Although communication between neurons is considered a function of the synapse, neurons also release neurotransmitter from their dendrites. We found that dendritic transmitter release coordinates activity across distinct neuronal populations to generate integrative homeostatic responses. We show that activity-dependent vasopressin release from hypothalamic neuroendocrine neurons in the paraventricular nucleus stimulates neighboring (~100μm soma-to-soma) presympathetic neurons, resulting in a sympathoexcitatory population response. This interpopulation crosstalk was engaged by an NMDA-mediated increase in dendritic Ca2+, influenced by vasopressin@s ability to diffuse in the extracellular space, and involved activation of CAN channels at the target neurons. Furthermore, we demonstrate that this interpopulation crosstalk plays a pivotal role in the generation of a systemic, polymodal neurohumoral response to a hyperosmotic challenge. Because dendritic release is emerging as a widespread process, our results suggest that a similar mechanism could mediate interpopulation crosstalk in other brain systems, particularly those involved in generating complex behaviors

Original languageEnglish (US)
Pages (from-to)1036-1049
Number of pages14
JournalNeuron
Volume78
Issue number6
DOIs
StatePublished - Jun 19 2013

Fingerprint

Neurons
Peptides
Carisoprodol
Vasopressins
Paraventricular Hypothalamic Nucleus
Extracellular Space
N-Methylaspartate
Dendrites
Synapses
Population
Neurotransmitter Agents
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Son, S. J., Filosa, J. A., Potapenko, E. S., Biancardi, V. C., Zheng, H., Patel, K. P., ... Stern, J. E. (2013). Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks. Neuron, 78(6), 1036-1049. https://doi.org/10.1016/j.neuron.2013.04.025

Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks. / Son, Sook Jin; Filosa, Jessica Andrea; Potapenko, Evgeniy S.; Biancardi, Vinicia Campana; Zheng, Hong; Patel, Kaushik P.; Tobin, Vicky A.; Ludwig, Mike; Stern, Javier Eduardo.

In: Neuron, Vol. 78, No. 6, 19.06.2013, p. 1036-1049.

Research output: Contribution to journalArticle

Son, SJ, Filosa, JA, Potapenko, ES, Biancardi, VC, Zheng, H, Patel, KP, Tobin, VA, Ludwig, M & Stern, JE 2013, 'Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks', Neuron, vol. 78, no. 6, pp. 1036-1049. https://doi.org/10.1016/j.neuron.2013.04.025
Son, Sook Jin ; Filosa, Jessica Andrea ; Potapenko, Evgeniy S. ; Biancardi, Vinicia Campana ; Zheng, Hong ; Patel, Kaushik P. ; Tobin, Vicky A. ; Ludwig, Mike ; Stern, Javier Eduardo. / Dendritic Peptide Release Mediates Interpopulation Crosstalk between Neurosecretory and Preautonomic Networks. In: Neuron. 2013 ; Vol. 78, No. 6. pp. 1036-1049.
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