Dentin permeability. Effects of desensitizing dentifrices in vitro.

D. H. Pashley, J. A. O'Meara, E. E. Kepler, S. E. Galloway, S. M. Thompson, F. P. Stewart

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Patients using placebo dentifrices in clinical trials usually show a significant decrease in dentin sensitivity over a 2- to 4-week period. If their sensitivity were due to hydrodynamic fluid movement, then the results suggest that there was a decrease in their dentin permeability. This hypothesis was tested in vitro by measuring the ease with which fluid could flow (i.e., hydraulic conductance) across dentin discs before and after brushing the discs with a variety of dentifrices, including most of the marketed densensitizing dentifrices. All dentifrices decreased the hydraulic conductance of dentin. An experimental dentifrice containing oxalate as the active ingredient was far more effective than any of the marketed dentifrices. The results tend to support the hypothesis that, at least part of the reduction in clinical sensitivity in patients with hypersensitive dentin is due to the abrasive action of the dentifrice.

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalJournal of Periodontology
Volume55
Issue number9
DOIs
StatePublished - Jan 1 1984

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Dentin Permeability
Dentifrices
Dentin
Dentin Sensitivity
Oxalates
Hydrodynamics
In Vitro Techniques
Placebos
Clinical Trials

ASJC Scopus subject areas

  • Periodontics

Cite this

Pashley, D. H., O'Meara, J. A., Kepler, E. E., Galloway, S. E., Thompson, S. M., & Stewart, F. P. (1984). Dentin permeability. Effects of desensitizing dentifrices in vitro. Journal of Periodontology, 55(9), 522-525. https://doi.org/10.1902/jop.1984.55.9.522

Dentin permeability. Effects of desensitizing dentifrices in vitro. / Pashley, D. H.; O'Meara, J. A.; Kepler, E. E.; Galloway, S. E.; Thompson, S. M.; Stewart, F. P.

In: Journal of Periodontology, Vol. 55, No. 9, 01.01.1984, p. 522-525.

Research output: Contribution to journalArticle

Pashley, DH, O'Meara, JA, Kepler, EE, Galloway, SE, Thompson, SM & Stewart, FP 1984, 'Dentin permeability. Effects of desensitizing dentifrices in vitro.', Journal of Periodontology, vol. 55, no. 9, pp. 522-525. https://doi.org/10.1902/jop.1984.55.9.522
Pashley DH, O'Meara JA, Kepler EE, Galloway SE, Thompson SM, Stewart FP. Dentin permeability. Effects of desensitizing dentifrices in vitro. Journal of Periodontology. 1984 Jan 1;55(9):522-525. https://doi.org/10.1902/jop.1984.55.9.522
Pashley, D. H. ; O'Meara, J. A. ; Kepler, E. E. ; Galloway, S. E. ; Thompson, S. M. ; Stewart, F. P. / Dentin permeability. Effects of desensitizing dentifrices in vitro. In: Journal of Periodontology. 1984 ; Vol. 55, No. 9. pp. 522-525.
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