Deoxyribonucleic acid analysis of the zinc finger Y gene in 45,X/46,XY subjects

L. Plouffe, A. Behzadian, S. P. Tho, Paul G McDonough

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The deoxyribonucleic acid from nine subjects with a 45,X/46,XY karyotype with a cytogenetically intact Y chromosome and phenotypically presenting with bilateral streak gonads, streak and testis, or bilateral scrotal testes along with a control male and female were analyzed for the presence of the zinc finger Y sequence through the molecular probe pDP1007. This particular probe is thought to constitute part of the putative testicular-determining factor gene. All the study subjects demonstrated the presence of zinc finger Y. Laser densitometry studies confirmed a correlation between the intensity of the zinc finger Y band and the percentage of Y cell lines. This study supports the fact that individuals with mixed gonadal dysgenesis and cytogenetically intact Y chromosomes will tend to have intact zinc finger Y sequences.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalFertility and Sterility
Volume54
Issue number2
DOIs
StatePublished - Jan 1 1990

Fingerprint

Zinc Fingers
Y Chromosome
DNA
Genes
Testis
Mixed Gonadal Dysgenesis
Molecular Probes
Densitometry
Gonads
Karyotype
Lasers
Cell Line

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Deoxyribonucleic acid analysis of the zinc finger Y gene in 45,X/46,XY subjects. / Plouffe, L.; Behzadian, A.; Tho, S. P.; McDonough, Paul G.

In: Fertility and Sterility, Vol. 54, No. 2, 01.01.1990, p. 265-269.

Research output: Contribution to journalArticle

Plouffe, L. ; Behzadian, A. ; Tho, S. P. ; McDonough, Paul G. / Deoxyribonucleic acid analysis of the zinc finger Y gene in 45,X/46,XY subjects. In: Fertility and Sterility. 1990 ; Vol. 54, No. 2. pp. 265-269.
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