Depolarization and cardiolipin depletion in aged rat brain mitochondria: Relationship with oxidative stress and electron transport chain activity

Tanusree Sen, Nilkantha Sen, Sirsendu Jana, Firoj Hossain Khan, Uttara Chatterjee, Sasanka Chakrabarti

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

A noticeable loss of cardiolipin, a significant accumulation of fluorescent products of lipid peroxidation and an increased ability to produce reactive oxygen species in vitro are characteristics of aged rat brain mitochondria, as has been demonstrated in this study. In contrast mitochondrial electron transport chain activity is not significantly compromised except a marginal decline in complex IV activity in aged rat brain. On the other hand, a striking loss of mitochondrial membrane potential occurs in brain mitochondria during aging, which may be attributed to peroxidative membrane damage in this condition. Such mitochondrial dysfunctions as reported here may lead to uncoupling of oxidative phosphorylation, ATP depletion and activation of apoptotic cascade in aged rat brain.

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalNeurochemistry International
Volume50
Issue number5
DOIs
StatePublished - Apr 1 2007

Keywords

  • Brain aging
  • Cardiolipin
  • Electron transport chain
  • Lipid peroxidation
  • Mitochondria
  • Mitochondrial membrane potential

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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