Depression, antidepressants, and falls among community-dwelling elderly people: The mobilize boston study

Lien Quach, Frances M. Yang, Sarah D. Berry, Elizabeth Newton, Richard N. Jones, Jeffrey A. Burr, Lewis A. Lipsitz

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background. The mechanisms linking falls and depression are still unknown. The aim of the study is to examine the association between depression and antidepressants, with indoor and outdoor falls, and to investigate how antidepressants mediate this relationship. Methods. The study included 763 men and women aged 70 and older with baseline measures for depression and antidepressant use are captured with prospective data on falls from the "Maintenance of Balance, Independent Living, Intellect and Zest in the Elderly" (MOBILIZE) Boston study, which is a population-based longitudinal study (from 2005 to 2009). Results. Overall, the rate of falls was 26 falls/100 person-years. Seventeen percent of participants had clinically significant depressive symptoms (CSDS), and 12% used antidepressants. CSDS increased the risk of indoor and outdoor falls (incidence rate ratio [IRR] = 1.6, 95% confidence interval [CI] = 1.2-2.3, p < .01; IRR = 1.6, 95% CI = 1.2-2.2, p < .01). Antidepressant use increased the risk of outdoor falls by 70% and partially mediated the association between CSDS and outdoor falls (IRR = 1.7, 95% CI = 1.2-2.5, p < .05). There was no relationship between antidepressant use and indoor falls. Similar results were observed when depression was considered as a continuous variable. Conclusions. Depression increased the risk of indoor and outdoor falls. Antidepressant use among older adults with CSDS increased the risk of outdoor, but not indoor falls. Clinicians should carefully consider the role of antidepressants among older adults with CSDS and their potential increase for the risk of outdoor falls.

Original languageEnglish (US)
Pages (from-to)1575-1581
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number12 A
DOIs
StatePublished - Jan 1 2013

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Independent Living
Antidepressive Agents
Depression
Confidence Intervals
Incidence
Longitudinal Studies
Maintenance

Keywords

  • Depression
  • Falls
  • Medication

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Depression, antidepressants, and falls among community-dwelling elderly people : The mobilize boston study. / Quach, Lien; Yang, Frances M.; Berry, Sarah D.; Newton, Elizabeth; Jones, Richard N.; Burr, Jeffrey A.; Lipsitz, Lewis A.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 68, No. 12 A, 01.01.2013, p. 1575-1581.

Research output: Contribution to journalArticle

Quach, Lien ; Yang, Frances M. ; Berry, Sarah D. ; Newton, Elizabeth ; Jones, Richard N. ; Burr, Jeffrey A. ; Lipsitz, Lewis A. / Depression, antidepressants, and falls among community-dwelling elderly people : The mobilize boston study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2013 ; Vol. 68, No. 12 A. pp. 1575-1581.
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