Depressive Symptoms and Metabolic Syndrome

Is Inflammation the Underlying Link?

Lucile Capuron, Shaoyong Su, Andrew H. Miller, J. Douglas Bremner, Jack Goldberg, Gerald J. Vogt, Carisa Maisano, Linda Jones, Nancy V. Murrah, Viola Vaccarino

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Background: Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity might be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship. Methods: Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam Era Twin Registry. Depressive symptoms were measured with the Beck Depression Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive). Results: Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education, and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore. Conclusions: The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.

Original languageEnglish (US)
Pages (from-to)896-900
Number of pages5
JournalBiological Psychiatry
Volume64
Issue number10
DOIs
StatePublished - Nov 15 2008
Externally publishedYes

Fingerprint

Depression
Inflammation
Equipment and Supplies
C-Reactive Protein
Interleukin-6
Vietnam
Innate Immunity
Statistical Factor Analysis
Registries
Cardiovascular Diseases
Biomarkers
Smoking
Education

Keywords

  • Cytokines
  • depression
  • inflammation
  • metabolic syndrome
  • mood

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Capuron, L., Su, S., Miller, A. H., Bremner, J. D., Goldberg, J., Vogt, G. J., ... Vaccarino, V. (2008). Depressive Symptoms and Metabolic Syndrome: Is Inflammation the Underlying Link? Biological Psychiatry, 64(10), 896-900. https://doi.org/10.1016/j.biopsych.2008.05.019

Depressive Symptoms and Metabolic Syndrome : Is Inflammation the Underlying Link? / Capuron, Lucile; Su, Shaoyong; Miller, Andrew H.; Bremner, J. Douglas; Goldberg, Jack; Vogt, Gerald J.; Maisano, Carisa; Jones, Linda; Murrah, Nancy V.; Vaccarino, Viola.

In: Biological Psychiatry, Vol. 64, No. 10, 15.11.2008, p. 896-900.

Research output: Contribution to journalArticle

Capuron, L, Su, S, Miller, AH, Bremner, JD, Goldberg, J, Vogt, GJ, Maisano, C, Jones, L, Murrah, NV & Vaccarino, V 2008, 'Depressive Symptoms and Metabolic Syndrome: Is Inflammation the Underlying Link?', Biological Psychiatry, vol. 64, no. 10, pp. 896-900. https://doi.org/10.1016/j.biopsych.2008.05.019
Capuron, Lucile ; Su, Shaoyong ; Miller, Andrew H. ; Bremner, J. Douglas ; Goldberg, Jack ; Vogt, Gerald J. ; Maisano, Carisa ; Jones, Linda ; Murrah, Nancy V. ; Vaccarino, Viola. / Depressive Symptoms and Metabolic Syndrome : Is Inflammation the Underlying Link?. In: Biological Psychiatry. 2008 ; Vol. 64, No. 10. pp. 896-900.
@article{28d0a576f00d40acaeb57f464d3237c3,
title = "Depressive Symptoms and Metabolic Syndrome: Is Inflammation the Underlying Link?",
abstract = "Background: Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity might be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship. Methods: Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam Era Twin Registry. Depressive symptoms were measured with the Beck Depression Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive). Results: Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education, and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore. Conclusions: The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.",
keywords = "Cytokines, depression, inflammation, metabolic syndrome, mood",
author = "Lucile Capuron and Shaoyong Su and Miller, {Andrew H.} and Bremner, {J. Douglas} and Jack Goldberg and Vogt, {Gerald J.} and Carisa Maisano and Linda Jones and Murrah, {Nancy V.} and Viola Vaccarino",
year = "2008",
month = "11",
day = "15",
doi = "10.1016/j.biopsych.2008.05.019",
language = "English (US)",
volume = "64",
pages = "896--900",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Depressive Symptoms and Metabolic Syndrome

T2 - Is Inflammation the Underlying Link?

AU - Capuron, Lucile

AU - Su, Shaoyong

AU - Miller, Andrew H.

AU - Bremner, J. Douglas

AU - Goldberg, Jack

AU - Vogt, Gerald J.

AU - Maisano, Carisa

AU - Jones, Linda

AU - Murrah, Nancy V.

AU - Vaccarino, Viola

PY - 2008/11/15

Y1 - 2008/11/15

N2 - Background: Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity might be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship. Methods: Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam Era Twin Registry. Depressive symptoms were measured with the Beck Depression Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive). Results: Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education, and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore. Conclusions: The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.

AB - Background: Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity might be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship. Methods: Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam Era Twin Registry. Depressive symptoms were measured with the Beck Depression Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive). Results: Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education, and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore. Conclusions: The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.

KW - Cytokines

KW - depression

KW - inflammation

KW - metabolic syndrome

KW - mood

UR - http://www.scopus.com/inward/record.url?scp=54149116720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54149116720&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2008.05.019

DO - 10.1016/j.biopsych.2008.05.019

M3 - Article

VL - 64

SP - 896

EP - 900

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 10

ER -