Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium

Festus Basden C. Okoye, Su Lu, Chukwuemeka S. Nworu, Charles O. Esimone, Peter Proksch, Ahmed Chadli, Abdessamad Debbab

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Chemical investigation of the ethyl acetate extract of Corynespora cassiicola, an endophytic fungus of Gongronema latifolium, afforded three new secondary metabolites, including corynesidone D (1), corynether B (2) and corynether lactone A (3), together with four known derivatives. The structures of the new compounds were deduced on the basis of 1D- and 2D-dimensional NMR spectroscopy as well as by high resolution mass spectrometry. Compounds 1 and 4-6 were tested for their ability to modulate the chaperoning activity of the Hsp90 chaperoning machine in vitro using 17-allylamino-demethoxygeldamycin (17-AAG) as a positive control. Unfortunately, no effect on the Hsp90 chaperoning machine has been observed.

Original languageEnglish (US)
Pages (from-to)4210-4214
Number of pages5
JournalTetrahedron Letters
Volume54
Issue number32
DOIs
StatePublished - Aug 7 2013

Keywords

  • Corynespora cassiicola
  • Endophytes
  • Heat shock protein 90 (Hsp90)
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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