Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study

Henrik Sillesen, Gregory Albers, Irfan Altafullah, Oscar Benavente, Diane Book, Joseph Broderick, Christopher Calder, Alfred S. Callahan, Walter Carlini, Seemant Chaturvedi, Thomas Chippendale, Wayne Clark, Greg Collins, Bruce Coull, Patricia Davis, Thomas Devlin, Arthur R. Dick, Lucy Younger Dirr-Ledbetter, George Dooneief, R. Scott Duff & 124 others Nordeli Estronza, Alejandro Forteza, Michael R. Frankel, James L. Frey, Gary Friday, Jerome Goldstein, Steven Goldstein, Gleen Graham, Wayne Harper, Jonathan Harris, Barry Hendin, David C Hess, Richard Hinton, Joshua Hollander, Chung Y. Hsu, Richard L. Hughes, Scott Kasner, T. A. Kent, Lance Kim, Howard Kirshner, Marian LaMonte, Kenneth Levin, Richard Libman, Paul McDowell, Francis E. McGee, Brett Meyer, Alireza Minagar, Frederick E. Munschauer, Richard Munson, Marshall Nash, Sean C. Orr, Gerald Ratinov, Virgilio Salanga, Souvik Sen, Scott Silliman, Richard Singer, Don Smith, Herman Sullivan, David Thaler, Gretchen Tietjen, Michael Tuchman, David Uskavitch, Piero Verro, Ralph Vicari, Richard Weinstein, Janet Wilterdink, Richard Zweifler, Michael Beaudry, Robert Cote, Keith Hoyte, Louise Helene Lebrun, John Norris, Daniel Selchen, Ashfaq Shuaib, Denis Simard, David Spence, Philip Teal, Michael Winger, Reinhold Schmidt, Bruno Pramsohler, Christoph Schmidauer, Markku Kaste, Juhani Sivenius, Anna Wagner, Andreas Terent, Pierre Amarenco, Loic Milandre, Francois Chollet, Thomas de Broucker, Thierry Moulin, Etienne Roullet, Didier Leys, Marie Helene Mahagne, Michael Hennerici, W. D. Heiss, Otto Busse, Roman Haberl, L. Harms, C. Diener, G. Hamann, E. Bemd Ringelstein, Nicola Canal, Antonio Capurso, Angelo Mamoli, Lodovico Frattola, Carlo Gandolfo, Umberto Senin, Michele Zito, Keyser de Keyser, The Netherlands, P. J. Koudstaal, J. A. Haas, G. de Jong, Julien Bogousslavsky, Heinrich Mattie, Ralf Baumgartner, R. S. MacWalter, Roelfe Dijkhuizen, Enefioke Ben Ekpo, Philip Bath, Kennedy R. Lees, Jose Ferro, Luis Cunha, Antonio Davalos, Angel Chamorro, Alvarez Sabin, Dolores Jimenez, Jose Ramon Gonzalez, Aida Lago, Jose Egido, Jose Vivancos, Matias Guiu, Geoffrey Dorman, Stephen Davis, David Gilles, Judy Frayne, Denis Crimmins, Simon Dimmit, Gagrath Pradeep Singh, Russell Scott, Neil Edward Anderson, J. Carr, A. K. Kruger, J. Gardiner

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for patients with cerebrovascular disease and no history of CHD remains uncertain. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate the effects of atorvastatin 80 mg/day in patients who previously experienced a stroke or transient ischaemic attack, but who have no known CHD. A total of 4,732 patients have been enrolled, and the data collection phase of the study is expected to be completed by October 2004. SPARCL is the first study primarily designed to prospectively evaluate the effect of statin treatment in secondary stroke prevention.

Original languageEnglish (US)
Pages (from-to)389-395
Number of pages7
JournalCerebrovascular Diseases
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2003

Fingerprint

Stroke
Cholesterol
Coronary Disease
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cerebrovascular Disorders
Transient Ischemic Attack
Secondary Prevention
Randomized Controlled Trials
Placebos
Therapeutics

Keywords

  • Atorvastatin
  • Cholesterol
  • Lipid
  • Statin
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Sillesen, H., Albers, G., Altafullah, I., Benavente, O., Book, D., Broderick, J., ... Gardiner, J. (2003). Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. Cerebrovascular Diseases, 16(4), 389-395. https://doi.org/10.1159/000072562

Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. / Sillesen, Henrik; Albers, Gregory; Altafullah, Irfan; Benavente, Oscar; Book, Diane; Broderick, Joseph; Calder, Christopher; Callahan, Alfred S.; Carlini, Walter; Chaturvedi, Seemant; Chippendale, Thomas; Clark, Wayne; Collins, Greg; Coull, Bruce; Davis, Patricia; Devlin, Thomas; Dick, Arthur R.; Dirr-Ledbetter, Lucy Younger; Dooneief, George; Duff, R. Scott; Estronza, Nordeli; Forteza, Alejandro; Frankel, Michael R.; Frey, James L.; Friday, Gary; Goldstein, Jerome; Goldstein, Steven; Graham, Gleen; Harper, Wayne; Harris, Jonathan; Hendin, Barry; Hess, David C; Hinton, Richard; Hollander, Joshua; Hsu, Chung Y.; Hughes, Richard L.; Kasner, Scott; Kent, T. A.; Kim, Lance; Kirshner, Howard; LaMonte, Marian; Levin, Kenneth; Libman, Richard; McDowell, Paul; McGee, Francis E.; Meyer, Brett; Minagar, Alireza; Munschauer, Frederick E.; Munson, Richard; Nash, Marshall; Orr, Sean C.; Ratinov, Gerald; Salanga, Virgilio; Sen, Souvik; Silliman, Scott; Singer, Richard; Smith, Don; Sullivan, Herman; Thaler, David; Tietjen, Gretchen; Tuchman, Michael; Uskavitch, David; Verro, Piero; Vicari, Ralph; Weinstein, Richard; Wilterdink, Janet; Zweifler, Richard; Beaudry, Michael; Cote, Robert; Hoyte, Keith; Lebrun, Louise Helene; Norris, John; Selchen, Daniel; Shuaib, Ashfaq; Simard, Denis; Spence, David; Teal, Philip; Winger, Michael; Schmidt, Reinhold; Pramsohler, Bruno; Schmidauer, Christoph; Kaste, Markku; Sivenius, Juhani; Wagner, Anna; Terent, Andreas; Amarenco, Pierre; Milandre, Loic; Chollet, Francois; de Broucker, Thomas; Moulin, Thierry; Roullet, Etienne; Leys, Didier; Mahagne, Marie Helene; Hennerici, Michael; Heiss, W. D.; Busse, Otto; Haberl, Roman; Harms, L.; Diener, C.; Hamann, G.; Ringelstein, E. Bemd; Canal, Nicola; Capurso, Antonio; Mamoli, Angelo; Frattola, Lodovico; Gandolfo, Carlo; Senin, Umberto; Zito, Michele; de Keyser, Keyser; Netherlands, The; Koudstaal, P. J.; Haas, J. A.; de Jong, G.; Bogousslavsky, Julien; Mattie, Heinrich; Baumgartner, Ralf; MacWalter, R. S.; Dijkhuizen, Roelfe; Ekpo, Enefioke Ben; Bath, Philip; Lees, Kennedy R.; Ferro, Jose; Cunha, Luis; Davalos, Antonio; Chamorro, Angel; Sabin, Alvarez; Jimenez, Dolores; Gonzalez, Jose Ramon; Lago, Aida; Egido, Jose; Vivancos, Jose; Guiu, Matias; Dorman, Geoffrey; Davis, Stephen; Gilles, David; Frayne, Judy; Crimmins, Denis; Dimmit, Simon; Singh, Gagrath Pradeep; Scott, Russell; Anderson, Neil Edward; Carr, J.; Kruger, A. K.; Gardiner, J.

In: Cerebrovascular Diseases, Vol. 16, No. 4, 01.01.2003, p. 389-395.

Research output: Contribution to journalArticle

Sillesen, H, Albers, G, Altafullah, I, Benavente, O, Book, D, Broderick, J, Calder, C, Callahan, AS, Carlini, W, Chaturvedi, S, Chippendale, T, Clark, W, Collins, G, Coull, B, Davis, P, Devlin, T, Dick, AR, Dirr-Ledbetter, LY, Dooneief, G, Duff, RS, Estronza, N, Forteza, A, Frankel, MR, Frey, JL, Friday, G, Goldstein, J, Goldstein, S, Graham, G, Harper, W, Harris, J, Hendin, B, Hess, DC, Hinton, R, Hollander, J, Hsu, CY, Hughes, RL, Kasner, S, Kent, TA, Kim, L, Kirshner, H, LaMonte, M, Levin, K, Libman, R, McDowell, P, McGee, FE, Meyer, B, Minagar, A, Munschauer, FE, Munson, R, Nash, M, Orr, SC, Ratinov, G, Salanga, V, Sen, S, Silliman, S, Singer, R, Smith, D, Sullivan, H, Thaler, D, Tietjen, G, Tuchman, M, Uskavitch, D, Verro, P, Vicari, R, Weinstein, R, Wilterdink, J, Zweifler, R, Beaudry, M, Cote, R, Hoyte, K, Lebrun, LH, Norris, J, Selchen, D, Shuaib, A, Simard, D, Spence, D, Teal, P, Winger, M, Schmidt, R, Pramsohler, B, Schmidauer, C, Kaste, M, Sivenius, J, Wagner, A, Terent, A, Amarenco, P, Milandre, L, Chollet, F, de Broucker, T, Moulin, T, Roullet, E, Leys, D, Mahagne, MH, Hennerici, M, Heiss, WD, Busse, O, Haberl, R, Harms, L, Diener, C, Hamann, G, Ringelstein, EB, Canal, N, Capurso, A, Mamoli, A, Frattola, L, Gandolfo, C, Senin, U, Zito, M, de Keyser, K, Netherlands, T, Koudstaal, PJ, Haas, JA, de Jong, G, Bogousslavsky, J, Mattie, H, Baumgartner, R, MacWalter, RS, Dijkhuizen, R, Ekpo, EB, Bath, P, Lees, KR, Ferro, J, Cunha, L, Davalos, A, Chamorro, A, Sabin, A, Jimenez, D, Gonzalez, JR, Lago, A, Egido, J, Vivancos, J, Guiu, M, Dorman, G, Davis, S, Gilles, D, Frayne, J, Crimmins, D, Dimmit, S, Singh, GP, Scott, R, Anderson, NE, Carr, J, Kruger, AK & Gardiner, J 2003, 'Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study', Cerebrovascular Diseases, vol. 16, no. 4, pp. 389-395. https://doi.org/10.1159/000072562
Sillesen, Henrik ; Albers, Gregory ; Altafullah, Irfan ; Benavente, Oscar ; Book, Diane ; Broderick, Joseph ; Calder, Christopher ; Callahan, Alfred S. ; Carlini, Walter ; Chaturvedi, Seemant ; Chippendale, Thomas ; Clark, Wayne ; Collins, Greg ; Coull, Bruce ; Davis, Patricia ; Devlin, Thomas ; Dick, Arthur R. ; Dirr-Ledbetter, Lucy Younger ; Dooneief, George ; Duff, R. Scott ; Estronza, Nordeli ; Forteza, Alejandro ; Frankel, Michael R. ; Frey, James L. ; Friday, Gary ; Goldstein, Jerome ; Goldstein, Steven ; Graham, Gleen ; Harper, Wayne ; Harris, Jonathan ; Hendin, Barry ; Hess, David C ; Hinton, Richard ; Hollander, Joshua ; Hsu, Chung Y. ; Hughes, Richard L. ; Kasner, Scott ; Kent, T. A. ; Kim, Lance ; Kirshner, Howard ; LaMonte, Marian ; Levin, Kenneth ; Libman, Richard ; McDowell, Paul ; McGee, Francis E. ; Meyer, Brett ; Minagar, Alireza ; Munschauer, Frederick E. ; Munson, Richard ; Nash, Marshall ; Orr, Sean C. ; Ratinov, Gerald ; Salanga, Virgilio ; Sen, Souvik ; Silliman, Scott ; Singer, Richard ; Smith, Don ; Sullivan, Herman ; Thaler, David ; Tietjen, Gretchen ; Tuchman, Michael ; Uskavitch, David ; Verro, Piero ; Vicari, Ralph ; Weinstein, Richard ; Wilterdink, Janet ; Zweifler, Richard ; Beaudry, Michael ; Cote, Robert ; Hoyte, Keith ; Lebrun, Louise Helene ; Norris, John ; Selchen, Daniel ; Shuaib, Ashfaq ; Simard, Denis ; Spence, David ; Teal, Philip ; Winger, Michael ; Schmidt, Reinhold ; Pramsohler, Bruno ; Schmidauer, Christoph ; Kaste, Markku ; Sivenius, Juhani ; Wagner, Anna ; Terent, Andreas ; Amarenco, Pierre ; Milandre, Loic ; Chollet, Francois ; de Broucker, Thomas ; Moulin, Thierry ; Roullet, Etienne ; Leys, Didier ; Mahagne, Marie Helene ; Hennerici, Michael ; Heiss, W. D. ; Busse, Otto ; Haberl, Roman ; Harms, L. ; Diener, C. ; Hamann, G. ; Ringelstein, E. Bemd ; Canal, Nicola ; Capurso, Antonio ; Mamoli, Angelo ; Frattola, Lodovico ; Gandolfo, Carlo ; Senin, Umberto ; Zito, Michele ; de Keyser, Keyser ; Netherlands, The ; Koudstaal, P. J. ; Haas, J. A. ; de Jong, G. ; Bogousslavsky, Julien ; Mattie, Heinrich ; Baumgartner, Ralf ; MacWalter, R. S. ; Dijkhuizen, Roelfe ; Ekpo, Enefioke Ben ; Bath, Philip ; Lees, Kennedy R. ; Ferro, Jose ; Cunha, Luis ; Davalos, Antonio ; Chamorro, Angel ; Sabin, Alvarez ; Jimenez, Dolores ; Gonzalez, Jose Ramon ; Lago, Aida ; Egido, Jose ; Vivancos, Jose ; Guiu, Matias ; Dorman, Geoffrey ; Davis, Stephen ; Gilles, David ; Frayne, Judy ; Crimmins, Denis ; Dimmit, Simon ; Singh, Gagrath Pradeep ; Scott, Russell ; Anderson, Neil Edward ; Carr, J. ; Kruger, A. K. ; Gardiner, J. / Design and baseline characteristics of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study. In: Cerebrovascular Diseases. 2003 ; Vol. 16, No. 4. pp. 389-395.
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AU - Book, Diane

AU - Broderick, Joseph

AU - Calder, Christopher

AU - Callahan, Alfred S.

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AU - Chaturvedi, Seemant

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AU - Clark, Wayne

AU - Collins, Greg

AU - Coull, Bruce

AU - Davis, Patricia

AU - Devlin, Thomas

AU - Dick, Arthur R.

AU - Dirr-Ledbetter, Lucy Younger

AU - Dooneief, George

AU - Duff, R. Scott

AU - Estronza, Nordeli

AU - Forteza, Alejandro

AU - Frankel, Michael R.

AU - Frey, James L.

AU - Friday, Gary

AU - Goldstein, Jerome

AU - Goldstein, Steven

AU - Graham, Gleen

AU - Harper, Wayne

AU - Harris, Jonathan

AU - Hendin, Barry

AU - Hess, David C

AU - Hinton, Richard

AU - Hollander, Joshua

AU - Hsu, Chung Y.

AU - Hughes, Richard L.

AU - Kasner, Scott

AU - Kent, T. A.

AU - Kim, Lance

AU - Kirshner, Howard

AU - LaMonte, Marian

AU - Levin, Kenneth

AU - Libman, Richard

AU - McDowell, Paul

AU - McGee, Francis E.

AU - Meyer, Brett

AU - Minagar, Alireza

AU - Munschauer, Frederick E.

AU - Munson, Richard

AU - Nash, Marshall

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AU - Ratinov, Gerald

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AU - Sen, Souvik

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AU - Singer, Richard

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AU - Beaudry, Michael

AU - Cote, Robert

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AU - Norris, John

AU - Selchen, Daniel

AU - Shuaib, Ashfaq

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AU - Teal, Philip

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AU - Schmidauer, Christoph

AU - Kaste, Markku

AU - Sivenius, Juhani

AU - Wagner, Anna

AU - Terent, Andreas

AU - Amarenco, Pierre

AU - Milandre, Loic

AU - Chollet, Francois

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AU - Moulin, Thierry

AU - Roullet, Etienne

AU - Leys, Didier

AU - Mahagne, Marie Helene

AU - Hennerici, Michael

AU - Heiss, W. D.

AU - Busse, Otto

AU - Haberl, Roman

AU - Harms, L.

AU - Diener, C.

AU - Hamann, G.

AU - Ringelstein, E. Bemd

AU - Canal, Nicola

AU - Capurso, Antonio

AU - Mamoli, Angelo

AU - Frattola, Lodovico

AU - Gandolfo, Carlo

AU - Senin, Umberto

AU - Zito, Michele

AU - de Keyser, Keyser

AU - Netherlands, The

AU - Koudstaal, P. J.

AU - Haas, J. A.

AU - de Jong, G.

AU - Bogousslavsky, Julien

AU - Mattie, Heinrich

AU - Baumgartner, Ralf

AU - MacWalter, R. S.

AU - Dijkhuizen, Roelfe

AU - Ekpo, Enefioke Ben

AU - Bath, Philip

AU - Lees, Kennedy R.

AU - Ferro, Jose

AU - Cunha, Luis

AU - Davalos, Antonio

AU - Chamorro, Angel

AU - Sabin, Alvarez

AU - Jimenez, Dolores

AU - Gonzalez, Jose Ramon

AU - Lago, Aida

AU - Egido, Jose

AU - Vivancos, Jose

AU - Guiu, Matias

AU - Dorman, Geoffrey

AU - Davis, Stephen

AU - Gilles, David

AU - Frayne, Judy

AU - Crimmins, Denis

AU - Dimmit, Simon

AU - Singh, Gagrath Pradeep

AU - Scott, Russell

AU - Anderson, Neil Edward

AU - Carr, J.

AU - Kruger, A. K.

AU - Gardiner, J.

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AB - Evidence suggests that statin therapy reduces the risk of stroke in patients with coronary heart disease (CHD), but its benefit for patients with cerebrovascular disease and no history of CHD remains uncertain. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study is a prospective, multi-centre, double-blind, randomised, placebo-controlled trial designed to evaluate the effects of atorvastatin 80 mg/day in patients who previously experienced a stroke or transient ischaemic attack, but who have no known CHD. A total of 4,732 patients have been enrolled, and the data collection phase of the study is expected to be completed by October 2004. SPARCL is the first study primarily designed to prospectively evaluate the effect of statin treatment in secondary stroke prevention.

KW - Atorvastatin

KW - Cholesterol

KW - Lipid

KW - Statin

KW - Stroke

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