Design and synthesis: Novel quinazolin incorporated azetidinones and thiazolidinones as sedative, antibacterial and antifungal agents

S. S. Panda, P. V.R. Chowdary, S. Rani

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Several 3-chloro-1-[(2-phenylquinazolin-4-yl) oxy acetamidyl]-4- (substituted aryl)-2-azetidinones and 2-(substituted aryl)-3-[(2- phenylquinazolin-4-yl) oxy acetamidyl]-4-thiazolidinones were prepared by condensing 2-phenyl-4-(substituted benzylidine hydrazido methyloxy) quinazolines with chloroacetyl chloride and mercapto acetic acid respectively. These structures were established by IR and 1HNMR spectral data. These synthesized compounds were tested for their sedative, antibacterial and antifungal activities.

Original languageEnglish (US)
Pages (from-to)84-89
Number of pages6
JournalIndian Drugs
Volume45
Issue number2
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Antibacterial agents
  • Antifungal agents
  • Azitidinone
  • Quinazoline
  • Sedative activity
  • Thiazolidinone

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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