Design of a phantom equivalent to measure bone-fluorine in a human's hand via delayed neutron activation analysis

F. Mostafaei, F. E. McNeill, D. R. Chettle, W. V. Prestwich, M. Inskip

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fluorine is an element that can be either beneficial or harmful, depending on the total amount accumulated in the teeth or bones. In our laboratory, we have developed a non-invasive technique for the in vivo measurement of fluoride in bone using neutron activation analysis and performed the first pilot human study. Fluoride in humans is quantified by comparing the γ-ray signal from a person to the γ-ray signal obtained from appropriate anthropomorphic calibration phantoms. An identified problem with existing fluoride phantoms is contamination with aluminum. Aluminum creates an interfering γ-ray signal which, although it can be subtracted out, increases the uncertainty in the measurement and worsens the detection limit. This paper outlines a series of studies undertaken to develop a better calibration phantom for fluorine measurement, which does not have aluminum contamination.

Original languageEnglish (US)
Pages (from-to)503-512
Number of pages10
JournalPhysiological Measurement
Volume34
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Keywords

  • bone-fluorine
  • delayed neutron activation analysis
  • phantom

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Biomedical Engineering
  • Physiology (medical)

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