Detecting changes during pregnancy with Raman spectroscopy

Elizabeth Vargis, Kesha Robertson, Ayman Al-Hendy, Jeff Reese, Anita Mahadevan-Jansen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Preterm labor is the second leading cause of neonatal mortality and leads to a myriad of complications like delayed development and cerebral palsy. Currently, there is no way to accurately predict preterm labor, making its prevention and treatment virtually impossible. While there are some at-risk patients, over half of all preterm births do not fall into any high-risk category. This study seeks to predict and prevent preterm labor by using Raman spectroscopy to detect changes in the cervix during pregnancy. Since Raman spectroscopy has been used to detect cancers in vivo in organs like the cervix and skin, it follows that spectra will change over the course of pregnancy. Previous studies have shown that fluorescence decreased during pregnancy and increased during post-partum exams to pre-pregnancy levels. We believe significant changes will occur in the Raman spectra obtained during the course of pregnancy. In this study, Raman spectra from the cervix of pregnant mice and women will be acquired. Specific changes that occur due to cervical softening or changes in hormonal levels will be observed to understand the likelihood that a female mouse or a woman will enter labor.

Original languageEnglish (US)
Title of host publicationBiomedical Vibrational Spectroscopy IV
Subtitle of host publicationAdvances in Research and Industry
DOIs
StatePublished - May 7 2010
EventBiomedical Vibrational Spectroscopy IV: Advances in Research and Industry - San Francisco, CA, United States
Duration: Jan 23 2010Jan 25 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7560
ISSN (Print)1605-7422

Other

OtherBiomedical Vibrational Spectroscopy IV: Advances in Research and Industry
CountryUnited States
CitySan Francisco, CA
Period1/23/101/25/10

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Keywords

  • Cervix
  • Hormones
  • Obstetrics
  • T-test

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Vargis, E., Robertson, K., Al-Hendy, A., Reese, J., & Mahadevan-Jansen, A. (2010). Detecting changes during pregnancy with Raman spectroscopy. In Biomedical Vibrational Spectroscopy IV: Advances in Research and Industry [75600H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7560). https://doi.org/10.1117/12.843005