TY - JOUR
T1 - Detecting joint inflammation by an LED-based photoacoustic imaging system
T2 - A feasibility study
AU - Jo, Junggun
AU - Xu, Guan
AU - Zhu, Yunhao
AU - Burton, Mary
AU - Sarazin, Jeffrey
AU - Schiopu, Elena
AU - Gandikota, Girish
AU - Wang, Xueding
N1 - Funding Information:
This research was funded by the National Institute of Health (R01AR060350, 5R21AI122098-02) and Michigan Institute for Clinical and Health Research (MICHR) (UL1TR000433).
Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Light-emitting diode (LED) light sources have recently been introduced to photoacoustic imaging (PAI). The LEDs enable a smaller footprint for PAI systems when compared to laser sources, thereby improving system portability and allowing for improved access. An LED-based PAI system has been employed to identify inflammatory arthritis in human hand joints. B-mode ultrasound (US), Doppler, and PAIs were obtained from 12 joints with clinically active arthritis, five joints with subclinically active arthritis, and 12 normal joints. The quantitative assessment of hyperemia in joints by PAI demonstrated statistically significant differences among the three conditions. The imaging results from the subclinically active arthritis joints also suggested that the LED-based PAI has a higher sensitivity to angiogenic microvascularity compared to US Doppler imaging. This initial clinical study on arthritis patients validates that PAI can be a potential imaging modality for the diagnosis of inflammatory arthritis.
AB - Light-emitting diode (LED) light sources have recently been introduced to photoacoustic imaging (PAI). The LEDs enable a smaller footprint for PAI systems when compared to laser sources, thereby improving system portability and allowing for improved access. An LED-based PAI system has been employed to identify inflammatory arthritis in human hand joints. B-mode ultrasound (US), Doppler, and PAIs were obtained from 12 joints with clinically active arthritis, five joints with subclinically active arthritis, and 12 normal joints. The quantitative assessment of hyperemia in joints by PAI demonstrated statistically significant differences among the three conditions. The imaging results from the subclinically active arthritis joints also suggested that the LED-based PAI has a higher sensitivity to angiogenic microvascularity compared to US Doppler imaging. This initial clinical study on arthritis patients validates that PAI can be a potential imaging modality for the diagnosis of inflammatory arthritis.
KW - inflammatory arthritis
KW - joint
KW - light-emitting diode
KW - photoacoustic imaging
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U2 - 10.1117/1.JBO.23.11.110501
DO - 10.1117/1.JBO.23.11.110501
M3 - Article
C2 - 30499263
AN - SCOPUS:85057526636
SN - 1083-3668
VL - 23
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 11
M1 - 110501
ER -