Detection of angina-provoking coronary stenosis by resting iodine 123 metaiodobenzylguanidine scintigraphy in patients with unstable angina pectoris

Hiroyki Tsutsui, Shin ichi Ando, Tohru Fukai, Mari Kuroiwa, Kensuke Egashira, Masayuki Sasaki, Yasuo Kuwabara, Samon Koyanagi, Akira Takeshita

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Resting iodine 123-labeled metaiodobenzylguanidine (125I-MIGB) scintigraphy was performed in 19 patients with unstable angina to determine if it can detect myocardial ischemia and identity the angina-provoking coronary artery. Visual assessment of 123I-MIBG single-photon-emission computed tomograms was related to coronary vessel stenoses revealed by artariography at each vascular territory. Fourteen (74%) of 19 patients had regional 123I-MIBG-identified defects at areas with preserved thallium-201 perfusion. 123I-MIBG defects were highly positive at areas supplied by angina-provoking coronary arteries. The sensitivity and specificity of 123I-MIBG defects for identifying the angina-provoking coronary vessel were 71% and 78%, respectively. The interval between the most recent angina attack and imaging was shorter and the angina occurred more commonly after admission in patients with 123I-MIBG defects than in those without defects. These data suggest that repetitive myocardial ischemia impairs regional 123I-MIBG uptake and that this impairment persists for several days after perfusion has been restored. Thus resting 123I-MIBG scintigraphy is a useful noninvasive method to detect coronary stenoses provoking repetitive ischemia in patients with unstable angina in its acute phase.

Original languageEnglish (US)
Pages (from-to)708-715
Number of pages8
JournalAmerican Heart Journal
Volume129
Issue number4
DOIs
StatePublished - Apr 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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