Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue

B. B. Wray, C. Gaughf, F. W. Chandler, S. S. Berry, J. E. Latham, L. Wood, R. H. DuRant

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with chronic fatigue as a major complaint frequently present with recurrent sore throat, and on physical examination they have hyperemia and lymphoid hyperplasia of the pharyngeal area. Pharyngeal scrapings were obtained from 41 such patients and analyzed for Epstein-Barr virus or cytomegalovirus DNA by colorimetric in situ hybridization. Results were compared with healthy control subjects matched for age and sex. Epstein-Barr virus-DNA was detected more frequently in male patients, 5/9 (55.6%), than controls, 0/6 (0%), but there was no difference in frequency in female patients, 4/32 (12.5%), than control subjects, 1/29 (3.4%). Cytomegalovirus- DNA was detected infrequently in patients and controls, 13% versus 22% respectively. The presence of EBV-DNA did not correlate with antibody titers nor with the complaint of sore throat. Four of the five males who had positive EBV-DNA in the pharyngeal smears have now recovered.

Original languageEnglish (US)
Pages (from-to)223-226
Number of pages4
JournalAnnals of Allergy
Volume71
Issue number3
StatePublished - Jan 1 1993

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Cytomegalovirus
Human Herpesvirus 4
Fatigue
DNA
Pharyngitis
Hyperemia
Physical Examination
Hyperplasia
In Situ Hybridization
Healthy Volunteers
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Wray, B. B., Gaughf, C., Chandler, F. W., Berry, S. S., Latham, J. E., Wood, L., & DuRant, R. H. (1993). Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue. Annals of Allergy, 71(3), 223-226.

Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue. / Wray, B. B.; Gaughf, C.; Chandler, F. W.; Berry, S. S.; Latham, J. E.; Wood, L.; DuRant, R. H.

In: Annals of Allergy, Vol. 71, No. 3, 01.01.1993, p. 223-226.

Research output: Contribution to journalArticle

Wray, BB, Gaughf, C, Chandler, FW, Berry, SS, Latham, JE, Wood, L & DuRant, RH 1993, 'Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue', Annals of Allergy, vol. 71, no. 3, pp. 223-226.
Wray BB, Gaughf C, Chandler FW, Berry SS, Latham JE, Wood L et al. Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue. Annals of Allergy. 1993 Jan 1;71(3):223-226.
Wray, B. B. ; Gaughf, C. ; Chandler, F. W. ; Berry, S. S. ; Latham, J. E. ; Wood, L. ; DuRant, R. H. / Detection of Epstein-Barr virus and cytomegalovirus in patients with chronic fatigue. In: Annals of Allergy. 1993 ; Vol. 71, No. 3. pp. 223-226.
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