Determinants of plasma leptin concentration in postmenopausal women

Esther M. Brooks-Asplund, Carrie E. Tupper, Jane M. Daun, W. Larry Kenney, Joseph Gerard Cannon

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This investigation examined the influence of hormone replacement therapy on plasma leptin concentrations in postmenopausal women and sought to determine if a relationship existed between plasma leptin, the thermoregulatory cytokine interleukin-1 (IL-1), and basal body temperature. Twenty-two women (54-71 years of age) were studied: eight were not taking hormone replacement, seven took oral estrogen only, and seven took oral estrogen plus progestin. Morning oral temperature, plasma leptin concentration, and mononuclear cell secretion of IL-1β, IL-1 receptor antagonist (IL-1Ra), and soluble IL-1 receptor type II (sIL-1RII) were measured. Plasma leptin concentrations were not affected by hormone replacement therapy, but were inversely related to years since menopause (R=-0.48, P=0.02) and were proportional to IL-1 activity (the balance of IL-1β/IL-1Ra secretion, R=0.69, P=0.001). Moreover, morning oral temperature was positively related to plasma leptin (P=0.03), after stratifying by progestin intake. These results support the concept that basal body temperature is regulated by a network of endocrine and immune mediators that are significantly influenced by age.

Original languageEnglish (US)
Pages (from-to)117-119
Number of pages3
JournalMechanisms of Ageing and Development
Volume125
Issue number2
DOIs
StatePublished - Jan 1 2004

Fingerprint

Leptin
Interleukin-1
Interleukin-1 Receptors
Hormone Replacement Therapy
Progestins
Body Temperature
Interleukin-1 Type II Receptors
Estrogens
Temperature
Menopause
Hormones
Cytokines

Keywords

  • Age
  • Interleukin-1
  • Leptin
  • Progesterone

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Cite this

Brooks-Asplund, E. M., Tupper, C. E., Daun, J. M., Kenney, W. L., & Cannon, J. G. (2004). Determinants of plasma leptin concentration in postmenopausal women. Mechanisms of Ageing and Development, 125(2), 117-119. https://doi.org/10.1016/j.mad.2003.11.006

Determinants of plasma leptin concentration in postmenopausal women. / Brooks-Asplund, Esther M.; Tupper, Carrie E.; Daun, Jane M.; Kenney, W. Larry; Cannon, Joseph Gerard.

In: Mechanisms of Ageing and Development, Vol. 125, No. 2, 01.01.2004, p. 117-119.

Research output: Contribution to journalArticle

Brooks-Asplund, EM, Tupper, CE, Daun, JM, Kenney, WL & Cannon, JG 2004, 'Determinants of plasma leptin concentration in postmenopausal women', Mechanisms of Ageing and Development, vol. 125, no. 2, pp. 117-119. https://doi.org/10.1016/j.mad.2003.11.006
Brooks-Asplund, Esther M. ; Tupper, Carrie E. ; Daun, Jane M. ; Kenney, W. Larry ; Cannon, Joseph Gerard. / Determinants of plasma leptin concentration in postmenopausal women. In: Mechanisms of Ageing and Development. 2004 ; Vol. 125, No. 2. pp. 117-119.
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