Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis

Carsten Schwarz, Patrick Vandeputte, Amandine Rougeron, Sandrine Giraud, Thomas Dugé De Bernonville, Ludovic Duvaux, Amandine Gastebois, Ana Alastruey-Izquierdo, Maria Teresa Martín-Gomez, Estrella Martin Mazuelos, Amparo Sole, Josep Cano, Javier Pemán, Guillermo Quindos, Françoise Botterel, Marie Elisabeth Bougnoux, Sharon Chen, Laurence Delhaès, Loïc Favennec, Stéphane Ranque & 11 others Ludwig Sedlacek, Joerg Steinmann, Jose Antonio Vazquez, Craig Williams, Wieland Meyer, Solène Le Gal, Gilles Nevez, Maxime Fleury, Nicolas Papon, Françoise Symoens, Jean Philippe Bouchara

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.

Original languageEnglish (US)
Pages (from-to)S42-S59
JournalMedical Mycology
Volume56
DOIs
StatePublished - Apr 1 2018

Fingerprint

Mycoses
Cystic Fibrosis
Respiratory Tract Infections
Scedosporium
Mycology
Bacteria
Inborn Genetic Diseases
Group Processes
Fungal Spores
Microbiota
Mucus
Infection
Respiratory System
Fungi
Yeasts
Biomarkers
Genome
Morbidity
Mortality
Therapeutics

Keywords

  • Scedosporium species
  • biological diagnosis
  • cystic fibrosis
  • fungal respiratory infections
  • pathogenic mechanisms
  • treatment

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Schwarz, C., Vandeputte, P., Rougeron, A., Giraud, S., Dugé De Bernonville, T., Duvaux, L., ... Bouchara, J. P. (2018). Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis. Medical Mycology, 56, S42-S59. https://doi.org/10.1093/mmy/myx106

Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis. / Schwarz, Carsten; Vandeputte, Patrick; Rougeron, Amandine; Giraud, Sandrine; Dugé De Bernonville, Thomas; Duvaux, Ludovic; Gastebois, Amandine; Alastruey-Izquierdo, Ana; Martín-Gomez, Maria Teresa; Mazuelos, Estrella Martin; Sole, Amparo; Cano, Josep; Pemán, Javier; Quindos, Guillermo; Botterel, Françoise; Bougnoux, Marie Elisabeth; Chen, Sharon; Delhaès, Laurence; Favennec, Loïc; Ranque, Stéphane; Sedlacek, Ludwig; Steinmann, Joerg; Vazquez, Jose Antonio; Williams, Craig; Meyer, Wieland; Le Gal, Solène; Nevez, Gilles; Fleury, Maxime; Papon, Nicolas; Symoens, Françoise; Bouchara, Jean Philippe.

In: Medical Mycology, Vol. 56, 01.04.2018, p. S42-S59.

Research output: Contribution to journalReview article

Schwarz, C, Vandeputte, P, Rougeron, A, Giraud, S, Dugé De Bernonville, T, Duvaux, L, Gastebois, A, Alastruey-Izquierdo, A, Martín-Gomez, MT, Mazuelos, EM, Sole, A, Cano, J, Pemán, J, Quindos, G, Botterel, F, Bougnoux, ME, Chen, S, Delhaès, L, Favennec, L, Ranque, S, Sedlacek, L, Steinmann, J, Vazquez, JA, Williams, C, Meyer, W, Le Gal, S, Nevez, G, Fleury, M, Papon, N, Symoens, F & Bouchara, JP 2018, 'Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis', Medical Mycology, vol. 56, pp. S42-S59. https://doi.org/10.1093/mmy/myx106
Schwarz C, Vandeputte P, Rougeron A, Giraud S, Dugé De Bernonville T, Duvaux L et al. Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis. Medical Mycology. 2018 Apr 1;56:S42-S59. https://doi.org/10.1093/mmy/myx106
Schwarz, Carsten ; Vandeputte, Patrick ; Rougeron, Amandine ; Giraud, Sandrine ; Dugé De Bernonville, Thomas ; Duvaux, Ludovic ; Gastebois, Amandine ; Alastruey-Izquierdo, Ana ; Martín-Gomez, Maria Teresa ; Mazuelos, Estrella Martin ; Sole, Amparo ; Cano, Josep ; Pemán, Javier ; Quindos, Guillermo ; Botterel, Françoise ; Bougnoux, Marie Elisabeth ; Chen, Sharon ; Delhaès, Laurence ; Favennec, Loïc ; Ranque, Stéphane ; Sedlacek, Ludwig ; Steinmann, Joerg ; Vazquez, Jose Antonio ; Williams, Craig ; Meyer, Wieland ; Le Gal, Solène ; Nevez, Gilles ; Fleury, Maxime ; Papon, Nicolas ; Symoens, Françoise ; Bouchara, Jean Philippe. / Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis. In: Medical Mycology. 2018 ; Vol. 56. pp. S42-S59.
@article{ebb3cb10d90346c791a1c86039586946,
title = "Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis",
abstract = "Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.",
keywords = "Scedosporium species, biological diagnosis, cystic fibrosis, fungal respiratory infections, pathogenic mechanisms, treatment",
author = "Carsten Schwarz and Patrick Vandeputte and Amandine Rougeron and Sandrine Giraud and {Dug{\'e} De Bernonville}, Thomas and Ludovic Duvaux and Amandine Gastebois and Ana Alastruey-Izquierdo and Mart{\'i}n-Gomez, {Maria Teresa} and Mazuelos, {Estrella Martin} and Amparo Sole and Josep Cano and Javier Pem{\'a}n and Guillermo Quindos and Fran{\cc}oise Botterel and Bougnoux, {Marie Elisabeth} and Sharon Chen and Laurence Delha{\`e}s and Lo{\"i}c Favennec and St{\'e}phane Ranque and Ludwig Sedlacek and Joerg Steinmann and Vazquez, {Jose Antonio} and Craig Williams and Wieland Meyer and {Le Gal}, Sol{\`e}ne and Gilles Nevez and Maxime Fleury and Nicolas Papon and Fran{\cc}oise Symoens and Bouchara, {Jean Philippe}",
year = "2018",
month = "4",
day = "1",
doi = "10.1093/mmy/myx106",
language = "English (US)",
volume = "56",
pages = "S42--S59",
journal = "Medical Mycology",
issn = "1369-3786",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis

AU - Schwarz, Carsten

AU - Vandeputte, Patrick

AU - Rougeron, Amandine

AU - Giraud, Sandrine

AU - Dugé De Bernonville, Thomas

AU - Duvaux, Ludovic

AU - Gastebois, Amandine

AU - Alastruey-Izquierdo, Ana

AU - Martín-Gomez, Maria Teresa

AU - Mazuelos, Estrella Martin

AU - Sole, Amparo

AU - Cano, Josep

AU - Pemán, Javier

AU - Quindos, Guillermo

AU - Botterel, Françoise

AU - Bougnoux, Marie Elisabeth

AU - Chen, Sharon

AU - Delhaès, Laurence

AU - Favennec, Loïc

AU - Ranque, Stéphane

AU - Sedlacek, Ludwig

AU - Steinmann, Joerg

AU - Vazquez, Jose Antonio

AU - Williams, Craig

AU - Meyer, Wieland

AU - Le Gal, Solène

AU - Nevez, Gilles

AU - Fleury, Maxime

AU - Papon, Nicolas

AU - Symoens, Françoise

AU - Bouchara, Jean Philippe

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.

AB - Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.

KW - Scedosporium species

KW - biological diagnosis

KW - cystic fibrosis

KW - fungal respiratory infections

KW - pathogenic mechanisms

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85044741992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044741992&partnerID=8YFLogxK

U2 - 10.1093/mmy/myx106

DO - 10.1093/mmy/myx106

M3 - Review article

VL - 56

SP - S42-S59

JO - Medical Mycology

JF - Medical Mycology

SN - 1369-3786

ER -