Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis

Carsten Schwarz, Patrick Vandeputte, Amandine Rougeron, Sandrine Giraud, Thomas Dugé De Bernonville, Ludovic Duvaux, Amandine Gastebois, Ana Alastruey-Izquierdo, Maria Teresa Martín-Gomez, Estrella Martin Mazuelos, Amparo Sole, Josep Cano, Javier Pemán, Guillermo Quindos, Françoise Botterel, Marie Elisabeth Bougnoux, Sharon Chen, Laurence Delhaès, Loïc Favennec, Stéphane RanqueLudwig Sedlacek, Joerg Steinmann, Jose Antonio Vazquez, Craig Williams, Wieland Meyer, Solène Le Gal, Gilles Nevez, Maxime Fleury, Nicolas Papon, Françoise Symoens, Jean Philippe Bouchara

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Cystic fibrosis (CF) is the major genetic inherited disease in Caucasian populations. The respiratory tract of CF patients displays a sticky viscous mucus, which allows for the entrapment of airborne bacteria and fungal spores and provides a suitable environment for growth of microorganisms, including numerous yeast and filamentous fungal species. As a consequence, respiratory infections are the major cause of morbidity and mortality in this clinical context. Although bacteria remain the most common agents of these infections, fungal respiratory infections have emerged as an important cause of disease. Therefore, the International Society for Human and Animal Mycology (ISHAM) has launched a working group on Fungal respiratory infections in Cystic Fibrosis (Fri-CF) in October 2006, which was subsequently approved by the European Confederation of Medical Mycology (ECMM). Meetings of this working group, comprising both clinicians and mycologists involved in the follow-up of CF patients, as well as basic scientists interested in the fungal species involved, provided the opportunity to initiate collaborative works aimed to improve our knowledge on these infections to assist clinicians in patient management. The current review highlights the outcomes of some of these collaborative works in clinical surveillance, pathogenesis and treatment, giving special emphasis to standardization of culture procedures, improvement of species identification methods including the development of nonculture-based diagnostic methods, microbiome studies and identification of new biological markers, and the description of genotyping studies aiming to differentiate transient carriage and chronic colonization of the airways. The review also reports on the breakthrough in sequencing the genomes of the main Scedosporium species as basis for a better understanding of the pathogenic mechanisms of these fungi, and discusses treatment options of infections caused by multidrug resistant microorganisms, such as Scedosporium and Lomentospora species and members of the Rasamsonia argillacea species complex.

Original languageEnglish (US)
Pages (from-to)S42-S59
JournalMedical Mycology
Volume56
DOIs
StatePublished - Apr 1 2018

Keywords

  • Scedosporium species
  • biological diagnosis
  • cystic fibrosis
  • fungal respiratory infections
  • pathogenic mechanisms
  • treatment

ASJC Scopus subject areas

  • Infectious Diseases

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    Schwarz, C., Vandeputte, P., Rougeron, A., Giraud, S., Dugé De Bernonville, T., Duvaux, L., Gastebois, A., Alastruey-Izquierdo, A., Martín-Gomez, M. T., Mazuelos, E. M., Sole, A., Cano, J., Pemán, J., Quindos, G., Botterel, F., Bougnoux, M. E., Chen, S., Delhaès, L., Favennec, L., ... Bouchara, J. P. (2018). Developing collaborative works for faster progress on fungal respiratory infections in cystic fibrosis. Medical Mycology, 56, S42-S59. https://doi.org/10.1093/mmy/myx106