Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration

Mari Dezawa, Hiroto Ishikawa, Yutaka Itokazu, Tomoyuki Yoshihara, Mikio Hoshino, Shin Ichi Takeda, Chizuka Ide, Yo Ichi Nabeshima

Research output: Contribution to journalArticle

485 Scopus citations

Abstract

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

Original languageEnglish (US)
Pages (from-to)314-317
Number of pages4
JournalScience
Volume309
Issue number5732
DOIs
StatePublished - Jul 8 2005
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Dezawa, M., Ishikawa, H., Itokazu, Y., Yoshihara, T., Hoshino, M., Takeda, S. I., Ide, C., & Nabeshima, Y. I. (2005). Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science, 309(5732), 314-317. https://doi.org/10.1126/science.1110364