Developmental Plasticity of Patterned and Regenerating Oral Organs

J. Todd Streelman, Ryan Fredric Bloomquist, Teresa E. Fowler

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In many aquatic vertebrates, including bony and cartilaginous fishes, teeth and taste buds colocalize on jaw elements. In these animals, taste buds are renewed continuously throughout life, whereas teeth undergo cycled whole-organ replacement by various means. Recently, studies of cichlid fishes have yielded new insights into the development and regeneration of these dental and sensory oral organs. Tooth and taste bud densities covary positively across species with different feeding strategies, controlled by common regions of the genome and integrated molecular signals. Developing teeth and taste buds share a bipotent epithelium during early patterning stages, from which dental and taste fields are specified. Moreover, these organs share a common epithelial ribbon that supports label-retaining cells during later stages of regeneration. During both patterning and regeneration stages, dental organs can be converted to taste bud fate by manipulation of BMP signaling. These observations highlight a surprising long-term plasticity between dental and sensory organ types. Here, we review these findings and discuss the implications of developmental plasticity that spans the continuum of craniofacial organ patterning and regeneration.

Original languageEnglish (US)
Title of host publicationCraniofacial Development, 2015
EditorsYang Chai
PublisherAcademic Press Inc.
Pages321-333
Number of pages13
ISBN (Print)9780124081413
DOIs
StatePublished - Jan 1 2015

Publication series

NameCurrent Topics in Developmental Biology
Volume115
ISSN (Print)0070-2153

Fingerprint

Taste Buds
Tooth
Regeneration
Cichlids
Jaw
Vertebrates
Fishes
Epithelium
Genome

Keywords

  • Development and regeneration
  • Patterning
  • Stem cell
  • Taste bud
  • Tooth

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Streelman, J. T., Bloomquist, R. F., & Fowler, T. E. (2015). Developmental Plasticity of Patterned and Regenerating Oral Organs. In Y. Chai (Ed.), Craniofacial Development, 2015 (pp. 321-333). (Current Topics in Developmental Biology; Vol. 115). Academic Press Inc.. https://doi.org/10.1016/bs.ctdb.2015.07.005

Developmental Plasticity of Patterned and Regenerating Oral Organs. / Streelman, J. Todd; Bloomquist, Ryan Fredric; Fowler, Teresa E.

Craniofacial Development, 2015. ed. / Yang Chai. Academic Press Inc., 2015. p. 321-333 (Current Topics in Developmental Biology; Vol. 115).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Streelman, JT, Bloomquist, RF & Fowler, TE 2015, Developmental Plasticity of Patterned and Regenerating Oral Organs. in Y Chai (ed.), Craniofacial Development, 2015. Current Topics in Developmental Biology, vol. 115, Academic Press Inc., pp. 321-333. https://doi.org/10.1016/bs.ctdb.2015.07.005
Streelman JT, Bloomquist RF, Fowler TE. Developmental Plasticity of Patterned and Regenerating Oral Organs. In Chai Y, editor, Craniofacial Development, 2015. Academic Press Inc. 2015. p. 321-333. (Current Topics in Developmental Biology). https://doi.org/10.1016/bs.ctdb.2015.07.005
Streelman, J. Todd ; Bloomquist, Ryan Fredric ; Fowler, Teresa E. / Developmental Plasticity of Patterned and Regenerating Oral Organs. Craniofacial Development, 2015. editor / Yang Chai. Academic Press Inc., 2015. pp. 321-333 (Current Topics in Developmental Biology).
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