Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Nagendran Muthusamy; Xuying Zhang; Caroline A. Johnson; Prem N. Yadav; H. Troy Ghashghaei

doi:10.1038/nn.4452

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Nagendran Muthusamy, Xuying Zhang, Caroline A. Johnson, Prem N. Yadav, H. Troy Ghashghaei

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.

Original language	English (US)
Pages (from-to)	20-23
Number of pages	4
Journal	Nature Neuroscience
Volume	20
Issue number	1
DOIs	https://doi.org/10.1038/nn.4452
State	Published - Jan 1 2017
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.4452

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Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Abstract

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