Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Nagendran Muthusamy, Xuying Zhang, Caroline A. Johnson, Prem N. Yadav, H. Troy Ghashghaei

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalNature Neuroscience
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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